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Acta Pharmaceutica, Vol. 61 No. 1, 2011.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-011-0001-y

Uporaba 2-aminoprop-1-en-1,1,3-trikarbonitrila u sintezi derivata tetrahidronaftalena, heksahidroizokinolina i heksahidrocinolina s potencijalnim antitumorskim djelovanjem

RAFAT M. MOHAREB ; October University for Modern Sciences and Arts, October City, A. R. Egypt
HOSAM E. MOUSTAFA ; Applied Medical Sciences Department, Community College in Quaryat, Al Jouf University, Al Jouf, Saudia Arabia

Puni tekst: engleski, pdf (97 KB) str. 51-62 preuzimanja: 512* citiraj
APA 6th Edition
MOHAREB, R.M. i MOUSTAFA, H.E. (2011). Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities. Acta Pharmaceutica, 61 (1), 51-62. https://doi.org/10.2478/v10007-011-0001-y
MLA 8th Edition
MOHAREB, RAFAT M. i HOSAM E. MOUSTAFA. "Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities." Acta Pharmaceutica, vol. 61, br. 1, 2011, str. 51-62. https://doi.org/10.2478/v10007-011-0001-y. Citirano 21.02.2019.
Chicago 17th Edition
MOHAREB, RAFAT M. i HOSAM E. MOUSTAFA. "Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities." Acta Pharmaceutica 61, br. 1 (2011): 51-62. https://doi.org/10.2478/v10007-011-0001-y
Harvard
MOHAREB, R.M., i MOUSTAFA, H.E. (2011). 'Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities', Acta Pharmaceutica, 61(1), str. 51-62. doi: https://doi.org/10.2478/v10007-011-0001-y
Vancouver
MOHAREB RM, MOUSTAFA HE. Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities. Acta Pharm. [Internet]. 2011 [pristupljeno 21.02.2019.];61(1):51-62. doi: https://doi.org/10.2478/v10007-011-0001-y
IEEE
R.M. MOHAREB i H.E. MOUSTAFA, "Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities", Acta Pharmaceutica, vol.61, br. 1, str. 51-62, 2011. [Online]. doi: https://doi.org/10.2478/v10007-011-0001-y

Sažetak
Cilj rada bio je sintetizirati heterocikličke spojeve polazeći od 2-aminoprop-1-en-1,1,3-trikarbonitrila. Taj spoj je prvo u reakciji s cikloheksanonom dao derivat etilidena 2, iz kojeg su zatim priređeni derivati tetrahidronaftalena, heksahidrokinolina i heksahidrocinolina. Novosintetizirani spojevi ispitani su na antitumorsko djelovanje in vitro na tri humane tumorske stanične linije: adenokarcinoma grudi (MCF-7), tumora pluća (NCI-H460) i tumora CNS-a (SF-268). Neki od ispitanih spojeva pokazali su snažan inhibitorni učinak na ispitivane stanične linije, što ukazuje na mogućnost njihove primjene u razvoju onkoloških lijekova.

Ključne riječi
tetrahidronaftalen; heksahidrokinolin; heksahidrocinolin; antitumorsko djelovanje

Hrčak ID: 63376

URI
https://hrcak.srce.hr/63376

[engleski]

Posjeta: 691 *