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Distribution of Major Brain Gangliosides in Olfactory Tract of Frogs

Barbara Viljetić
Ivan Večeslav Degmečić
Vinko Krajina
Tomislav Bogdanović
Ana Mojsović-Ćuić
Domagoj Đikić
Katarina Vajn
Ronald L. Schnaar
Marija Heffer

Puni tekst: engleski, pdf (181 KB) str. 121-126 preuzimanja: 327* citiraj
APA 6th Edition
Viljetić, B., Degmečić, I.V., Krajina, V., Bogdanović, T., Mojsović-Ćuić, A., Đikić, D., ... Heffer, M. (2011). Distribution of Major Brain Gangliosides in Olfactory Tract of Frogs. Collegium antropologicum, 35 supplement 1 (1), 121-126. Preuzeto s https://hrcak.srce.hr/64055
MLA 8th Edition
Viljetić, Barbara, et al. "Distribution of Major Brain Gangliosides in Olfactory Tract of Frogs." Collegium antropologicum, vol. 35 supplement 1, br. 1, 2011, str. 121-126. https://hrcak.srce.hr/64055. Citirano 29.07.2021.
Chicago 17th Edition
Viljetić, Barbara, Ivan Večeslav Degmečić, Vinko Krajina, Tomislav Bogdanović, Ana Mojsović-Ćuić, Domagoj Đikić, Katarina Vajn, Ronald L. Schnaar i Marija Heffer. "Distribution of Major Brain Gangliosides in Olfactory Tract of Frogs." Collegium antropologicum 35 supplement 1, br. 1 (2011): 121-126. https://hrcak.srce.hr/64055
Harvard
Viljetić, B., et al. (2011). 'Distribution of Major Brain Gangliosides in Olfactory Tract of Frogs', Collegium antropologicum, 35 supplement 1(1), str. 121-126. Preuzeto s: https://hrcak.srce.hr/64055 (Datum pristupa: 29.07.2021.)
Vancouver
Viljetić B, Degmečić IV, Krajina V, Bogdanović T, Mojsović-Ćuić A, Đikić D i sur. Distribution of Major Brain Gangliosides in Olfactory Tract of Frogs. Collegium antropologicum [Internet]. 2011 [pristupljeno 29.07.2021.];35 supplement 1(1):121-126. Dostupno na: https://hrcak.srce.hr/64055
IEEE
B. Viljetić, et al., "Distribution of Major Brain Gangliosides in Olfactory Tract of Frogs", Collegium antropologicum, vol.35 supplement 1, br. 1, str. 121-126, 2011. [Online]. Dostupno na: https://hrcak.srce.hr/64055. [Citirano: 29.07.2021.]

Sažetak
Gangliosides are major cell-surface determinants in the central nervous system (CNS) of vertebrates, found both in neuronal and glial cell membranes. Together with cholesterol and glycosylphosphatidylinositol (GPI) – anchored proteins, gangliosides are involved in organization of plasma membrane microdomains. Based on biochemical studies, frog brain was previously described as having low quantities of gangliosides and their distribution pattern in specific brain regions was unknown. Using highly specific monoclonal antibodies generated against four major brain gangliosides (GM1, GD1a, GD1b and GT1b), we examined the distribution of these molecules in CNS of four different species of frogs (Rana esculenta, Rana temporaria, Bufo bufo and Bufo viridis). We also studied the distribution of myelin- associated glycoprotein (MAG), an inhibitor of axonal regeneration, which is a ligand for gangliosides GD1a and GT1b. Our results show that ganglioside GD1a is expressed in neurons of olfactory bulb in all studied animals. In the brain of Rana sp., GD1a is expressed in the entire olfactory pathway, from olfactory bulbs to amygdala, while in Bufo sp. GD1a is restricted to the main olfactory bulb. Furthermore, we found that most of myelinated pathways in frogs express MAG, but do not express GD1a, which could be one of the reasons for better axon regeneration of neural pathways after CNS injury in amphibians in comparison to mammals.

Ključne riječi
gangliosides; myelin-associated glycoprotein (MAG); membrane microdomains; amphibians

Hrčak ID: 64055

URI
https://hrcak.srce.hr/64055

Posjeta: 643 *