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Hepatic and Pancreatic Glycosphingolipid Phenotypes of the Neurological Different Rat Strains

Jasminka Rešić
Vedrana Čikeš-Čulić
Tatijana Zemunik
Anita Markotić

Fulltext: english, pdf (140 KB) pages 259-263 downloads: 160* cite
APA 6th Edition
Rešić, J., Čikeš-Čulić, V., Zemunik, T. & Markotić, A. (2011). Hepatic and Pancreatic Glycosphingolipid Phenotypes of the Neurological Different Rat Strains. Collegium antropologicum, 35 supplement 1 (1), 259-263. Retrieved from https://hrcak.srce.hr/64089
MLA 8th Edition
Rešić, Jasminka, et al. "Hepatic and Pancreatic Glycosphingolipid Phenotypes of the Neurological Different Rat Strains." Collegium antropologicum, vol. 35 supplement 1, no. 1, 2011, pp. 259-263. https://hrcak.srce.hr/64089. Accessed 23 Jul. 2019.
Chicago 17th Edition
Rešić, Jasminka, Vedrana Čikeš-Čulić, Tatijana Zemunik and Anita Markotić. "Hepatic and Pancreatic Glycosphingolipid Phenotypes of the Neurological Different Rat Strains." Collegium antropologicum 35 supplement 1, no. 1 (2011): 259-263. https://hrcak.srce.hr/64089
Harvard
Rešić, J., et al. (2011). 'Hepatic and Pancreatic Glycosphingolipid Phenotypes of the Neurological Different Rat Strains', Collegium antropologicum, 35 supplement 1(1), pp. 259-263. Available at: https://hrcak.srce.hr/64089 (Accessed 23 July 2019)
Vancouver
Rešić J, Čikeš-Čulić V, Zemunik T, Markotić A. Hepatic and Pancreatic Glycosphingolipid Phenotypes of the Neurological Different Rat Strains. Collegium antropologicum [Internet]. 2011 [cited 2019 July 23];35 supplement 1(1):259-263. Available from: https://hrcak.srce.hr/64089
IEEE
J. Rešić, V. Čikeš-Čulić, T. Zemunik and A. Markotić, "Hepatic and Pancreatic Glycosphingolipid Phenotypes of the Neurological Different Rat Strains", Collegium antropologicum, vol.35 supplement 1, no. 1, pp. 259-263, 2011. [Online]. Available: https://hrcak.srce.hr/64089. [Accessed: 23 July 2019]

Abstracts
Among three commonly used strains of laboratory rats,Wistar rats perform more neurological tasks better then Lewis and Sprague-Dawley (SD) rats. Liver is the main site of insulin-like growth factor (IGF) production and pancreas is the exclusive site of insulin production. Insulin stimulates neuronal development and appropriate IGF-I input is critical in brain growth. Glycosphingolipids (GSLs) are important mediators of insulin secretion and action. Therefore, this study investigated GSL phenotypes of liver and pancreas with hypothesis that they are different in three rat strains. Total GSL fractions (neutral and gangliosides) were analysed by high performance thin-layer chromatography (HPTLC). Complex gangliosides were detected by HPTLC immunostaining using cholera toxin B subunit after neuraminidase pretreatment. Wistar rats had the highest liver weight/body weight ratio and SD rats had the highest pancreas weight/body weight ratio. Ganglioside GM3 was more expressed in the liver of Wistar compared to Lewis and SD rats. SD rats contained scarce quantities of GD1a and b-series gangliosides in the liver compared to Wistar and Lewis rats. Pancreatic b-series ganglioside content was also the lowest in SD rats. This study represents differences in the hepatic and pancreatic ganglioside phenotypes of three rat strains that could influence IGF and insulin secretion and action.

Keywords
b-series gangliosides; GM3; GD1a; liver; pancreas; rat strains

Hrčak ID: 64089

URI
https://hrcak.srce.hr/64089

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