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Spongious encephalopathy (1920–2010)

Mirko Jung ; Saumerstrasse 45, CH-8800, Švicarska

Puni tekst: hrvatski, pdf (3 MB) str. 177-194 preuzimanja: 600* citiraj
APA 6th Edition
Jung, M. (2010). Spongiozna encefalopatija (1920.–2010.). Infektološki glasnik, 30 (4), 177-194. Preuzeto s https://hrcak.srce.hr/66642
MLA 8th Edition
Jung, Mirko. "Spongiozna encefalopatija (1920.–2010.)." Infektološki glasnik, vol. 30, br. 4, 2010, str. 177-194. https://hrcak.srce.hr/66642. Citirano 21.10.2019.
Chicago 17th Edition
Jung, Mirko. "Spongiozna encefalopatija (1920.–2010.)." Infektološki glasnik 30, br. 4 (2010): 177-194. https://hrcak.srce.hr/66642
Harvard
Jung, M. (2010). 'Spongiozna encefalopatija (1920.–2010.)', Infektološki glasnik, 30(4), str. 177-194. Preuzeto s: https://hrcak.srce.hr/66642 (Datum pristupa: 21.10.2019.)
Vancouver
Jung M. Spongiozna encefalopatija (1920.–2010.). Infektološki glasnik [Internet]. 2010 [pristupljeno 21.10.2019.];30(4):177-194. Dostupno na: https://hrcak.srce.hr/66642
IEEE
M. Jung, "Spongiozna encefalopatija (1920.–2010.)", Infektološki glasnik, vol.30, br. 4, str. 177-194, 2010. [Online]. Dostupno na: https://hrcak.srce.hr/66642. [Citirano: 21.10.2019.]

Sažetak
We have studied the first prion diseases of which most cases were of genetic origin. They include point mutations (change in a single base pair Adenine/Guanine, Thymin/Cytosine) in the DNA, insertions of octapeptides in the N-part of the prion protein (3 to 216 octapeptide) and deletions (only two or three have been known until now). Three or more insertions are needed for the disease. They are 35 point mutations (the most frequent are at codon 102, 178 and 200). The newest variant CJD, which is caused by eating infected meat from infected beef is characterized by polimorphism Methionine/Methionone (M/M) at codon 129 in 98 percent of cases. The other cases of prion disease have no change in the prion genome. Point mutations are characterized by a single change in one base pair of 109 available in the human genome. Genetic prion diseases make up to 10-15 percent of all prion disease cases. Non genetic prion diseases are 85-90 percent; they together make up to 1,5-2,5 per million of inhabitants. Genetic prion diseases are simultaneously also infectious. PrPSc is needed for the diagnosis. Clinical diagnosis of genetic and nongenetic prion diseases appears very complicated. Genetic disease has sometimes anamnestic information on similar cases appearing in this or earlier generation. Genetic prion disease can be diagnosed by the study of base pairs by a laboratory method or by an automatic device or by Cytochemistry, Polymerase chain reaction, Western blot, Enzyme immunoassay (ELISA). Genetic methods need primers for the codon 102, 178 and 200. There are also autopsy, biopsy, electroneurodiagnostic and substances in the cerebrospinal fluid. The differential diagnostic to other diseases is very important. Most publications are from Prusiner, who received the Nobel prize. He changed recently his mind in eliminating the protein X and accepted clearly effects of foreign factors. PrPSc cannot originate from PrPC because both are proteins. The PrPSc is a product of the gene, i.e. that means it is nucleoprotein. We have summarized his ideas on genetic prion disease in the text. The infectivity of genetic and nongenetic prion diseases appears very low. The last 40 years tissue culture was tried: they were many times positive and the agents could be passaged. In 2007 a publication appeared as the virus of prion diseases was found. But many strains detected until now could only be compared with electron microscopic appearance. 20 to 50 nanometer great formations were found but the tissue itself did not function and a comparison was not possible. Several other neurotropic viruses were also found and this complicates the diagnosis of the prion agent. The tissue culture studies should be helped as evident from numerous publications in the world literature.

Ključne riječi
spongious encephalopathy; prions; genetics; slow viruses

Hrčak ID: 66642

URI
https://hrcak.srce.hr/66642

[hrvatski]

Posjeta: 893 *