Izvorni znanstveni članak

https://doi.org/10.2478/v10007-012-0002-5

Design and evaluation of moxifloxacin hydrochloride ocular insert

PRAVIN K. PAWAR ; Chitkara College of Pharmacy, Chitkara University, Chandigarh-Patiala National Highway, Rajpura, Rajpura-140401, Patiala, Punjab, India
RAJESH KATARA ; Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, (formerly College of Pharmacy), University of Delhi, Pushp Vihar, Sector III, New Delhi-110017, India
DIPAK K. MAJUMDAR ; Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, (formerly College of Pharmacy), University of Delhi, Pushp Vihar, Sector III, New Delhi-110017, India

Sažetak

The objective of the present investigation was to prepare and evaluate ocular inserts of moxifloxacin. An ocular insert was made from an aqueous dispersion of moxifloxacin, sodium alginate, polyvinyl alcohol, and dibutyl phthalate by the film casting method. The ocular insert (5.5 mm diameter) was cross-linked by CaCl2 and was coated with Eudragit S-100, RL-100, RS-100, E-100 or Eudragit L-100. The in vitro drug drainage/permeation studies were carried out using an all-glass modified Franz diffusion cell. The drug concentration and mucoadhesion time of the ocular insert were found satisfactory. Cross-linking and coating with polymers extended the drainage from inserts. The cross-linked ocular insert coated with Eudragit RL-100 showed maximum drug permeation compared to other formulations.

Ključne riječi

moxifloxacin; ocular insert; goat cornea

Hrčak ID:

76596

URI

https://hrcak.srce.hr/76596

Datum izdavanja:

31.3.2012.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.237 *