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The transforming properties of human papillomavirus oncoproteins

MAGDALENA GRCE   ORCID icon orcid.org/0000-0001-6178-8418 ; Department of Molecular Medicine, Ruđer Bošković Institute, Bijenička cesta 54, HR-10000 Zagreb, Croatia
IVAN SABOL   ORCID icon orcid.org/0000-0002-5753-8528 ; Department of Molecular Medicine, Ruđer Bošković Institute, Bijenička cesta 54, HR-10000 Zagreb, Croatia
NINA MILUTIN GAŠPEROV ; 1_Department of Molecular Medicine, Ruđer Bošković Institute, Bijenička cesta 54, HR-10000 Zagreb, Croatia; 2_Croatian Academy of Science and Arts, Department of Medical Sciences, Zrinski trg 11, HR-10000 Zagreb, Croatia

Puni tekst: engleski, pdf (222 KB) str. 479-487 preuzimanja: 673* citiraj
APA 6th Edition
GRCE, M., SABOL, I. i MILUTIN GAŠPEROV, N. (2012). The transforming properties of human papillomavirus oncoproteins. Periodicum biologorum, 114 (4), 479-487. Preuzeto s https://hrcak.srce.hr/101208
MLA 8th Edition
GRCE, MAGDALENA, et al. "The transforming properties of human papillomavirus oncoproteins." Periodicum biologorum, vol. 114, br. 4, 2012, str. 479-487. https://hrcak.srce.hr/101208. Citirano 11.08.2020.
Chicago 17th Edition
GRCE, MAGDALENA, IVAN SABOL i NINA MILUTIN GAŠPEROV. "The transforming properties of human papillomavirus oncoproteins." Periodicum biologorum 114, br. 4 (2012): 479-487. https://hrcak.srce.hr/101208
Harvard
GRCE, M., SABOL, I., i MILUTIN GAŠPEROV, N. (2012). 'The transforming properties of human papillomavirus oncoproteins', Periodicum biologorum, 114(4), str. 479-487. Preuzeto s: https://hrcak.srce.hr/101208 (Datum pristupa: 11.08.2020.)
Vancouver
GRCE M, SABOL I, MILUTIN GAŠPEROV N. The transforming properties of human papillomavirus oncoproteins. Periodicum biologorum [Internet]. 2012 [pristupljeno 11.08.2020.];114(4):479-487. Dostupno na: https://hrcak.srce.hr/101208
IEEE
M. GRCE, I. SABOL i N. MILUTIN GAŠPEROV, "The transforming properties of human papillomavirus oncoproteins", Periodicum biologorum, vol.114, br. 4, str. 479-487, 2012. [Online]. Dostupno na: https://hrcak.srce.hr/101208. [Citirano: 11.08.2020.]

Sažetak
Human papillomaviruses (HPV) are very common viruses, often causing
benign epithelial lesions but, rarely, also cancer. Only long persistent infection
with some carcinogenic or high risk HPV types will progress to
high-grade lesions and finally cancer. The oncogenic potential of these HR
HPV types relies on the role of their major oncoproteins E6 and E7, which
bind, inactivate and degrade the two major cellular tumor-suppressor gene
products, p53 and the retinoblastoma tumor-suppressor protein (pRb),
respectively. The continuous expression of these early oncoproteins can lead
to the transformation and immortalization of infected cells. Both, E6 and
E7 co-operate to induce transformation of epithelial cells by interacting
with numerous host cell proteins affecting many essential cellular pathways.
Herein, the current knowledge on HPV E6 and E7, as well as on the
auxiliary E5 oncoprotein is summarized.

Ključne riječi
human papillomavirus; HPV; oncogene; oncoprotein

Hrčak ID: 101208

URI
https://hrcak.srce.hr/101208

Posjeta: 850 *