Periodicum biologorum, Vol. 114 No. 4, 2012.
Izvorni znanstveni članak
Interleukin-1 gene locus polymorphisms are associated with risk to breast cancer in Croatian population
MARIKKEN HEILAND KAARVATN
; 1_Molecular Genetics Laboratory, Department of Oral Biology, University of Oslo, Norway; 2_School of Medicine, University of Oslo, Norway
RANDI KROG EFTEDAL
; Molecular Genetics Laboratory, Department of Oral Biology, University of Oslo, Norway
JURICA VRBANEC
; 1_Molecular Genetics Laboratory, Department of Oral Biology, University of Oslo, Norway; 2_School of Medicine, University of Zagreb, Croatia
ZDRAVKO JOTANOVIC
; 1_Molecular Genetics Laboratory, Department of Oral Biology, University of Oslo, Norway; 2_Clinic For Orthopaedic Surgery Lovran, School of Medicine, University of Rijeka, Croatia
GODFREY E. ETOKEBE
; Molecular Genetics Laboratory, Department of Oral Biology, University of Oslo, Norway
SANJA BALEN
; Clinical Institute for Transfusion Medicine, Universal Hospital Center Rijeka, School of Medicine, University of Rijeka, Croatia
ANA KULIC
; Department of Medical Oncology, Division of Oncology, University Hospital Center Zagreb, School of Medicine, University of Zagreb, Croatia
ZLATKO DEMBIC
; Department of Oral Biology, Sognsvannsveien 10, PB 1052 Blindern, 0316 Oslo, Norway
Sažetak
Breast cancer has a complex genetic susceptibility. Innate and adaptive immunity can additionally increase the genetic risk to breast cancer development. We typed polymorphisms in the genes of the interleukin(IL)-1 and IL-17 proinflammatory cytokines in a case-control study in Caucasian population from Croatia. We compared the allelic and genotypic frequencies between patients (n=194), healthy women (n=188) and general population (n=531). The risk for breast cancer has been significantly different at both allelic and genotypic levels for two polymorphisms: the IL1B gene single
nucleotide polymorphism (SNP) at -511 (G>A; rs16944) and the IL1
Receptor antagonist gene (IL1RN) variable number of tandem repeats
(VNTR). Themajor allele (G) of the IL1B rs16944 SNPwas associated with susceptibility to breast cancer (P<0.01) in general populationwith odds ratio (OR) of 1.42 and 95 % confidence interval (CI) at 1.09–1.85. The IL1RN VNTR allele 3 (5 repeats) was correlated with predisposition to disease (P<0.01,OR: 9.71, 95%CI: 1.34–198.51) inwomen. At the genotype level, G/G homozygosity at IL1B rs16944 was significantly associated with predisposition to disease (P<0.02, OR: 1.68, 95 % CI: 1.10–2.57), whereas the heterozygosity (G/A) was correlatedwith protection to disease (P<0.01, OR:
0.57, 95 % CI: 0.37–0.89) in women. The IL1RN VNTR genotype 1/3 was significantly associated with susceptibility to breast cancer (P<0.01, OR: 10.01, 95 % CI: 1.37–207.55). Genotypic differences were also significantly different in comparison with general population for IL1B SNP (P<0.001) and IL1RN VNTR (P<0.01). These results corroborate a premise that inflammatory factors play a role in pathogenesis to breast cancer.
Ključne riječi
Hrčak ID:
101268
URI
Datum izdavanja:
30.9.2012.
Posjeta: 1.720 *