Izvorni znanstveni članak

https://doi.org/10.5562/cca2071

Anaerobic Hydrolytic Degradation of Cefpodoxime Proxetil in the Presence of UV Irradiation and in Darkness: Kinetics and pH Effect

Ender Biçer ; Department of Chemistry, Faculty of Arts and Sciences, Ondokuz Mayıs University, 55139 Atakum-Samsun, Turkey
Neslihan Özdemir ; Department of Chemistry, Faculty of Arts and Sciences, Ondokuz Mayıs University, 55139 Atakum-Samsun, Turkey
Serkan Özdemir ; Department of Chemistry, Faculty of Arts and Sciences, Ondokuz Mayıs University, 55139 Atakum-Samsun, Turkey

Sažetak

In this study, the anaerobic hydrolytic degradation of cefpodoxime proxetil (CP) in the presence
of UV-light irradiation and in darkness has been studied at Britton-Robinson (B-R) buffer solutions (pH
2.5–11) by cyclic and square-wave voltammetry techniques. By means of these electrochemical techniques,
the hydrolytic degradation of CP was successfully followed. The pH effect on this degradation
was also investigated. In darkness, the decrease in the peak current of CP was not practically observed at
the acidic and physiological pHs (2.5, 5.0 and 7.4). But, in the basic medium (pH 9.0 and 11.0), a decrease
in the peak current was detected. On the other hand, UV irradiation caused a decrease in the peak current
of CP and a positive shift in its cathodic peak potential. Under the UV irradiation, the maximum stability
of CP was observed in B-R buffer of pH 5. It has been determined that UV irradiation has a great effect on
hydrolytic degradation of CP at basic medium. On the other hand, at pHs  7.4, a new peak has been also
obtained at more positive potential than that of the first reduction peak of CP. The current of this peak increases
by increasing UV irradiation time. This peak could be assigned to the reduction of a new
electroactive product which was formed from the hydrolytic degradation of CP under UV irradiation. The
hydrolytic degradation reaction of CP followed pseudo-first order kinetics.(doi: 10.5562/cca2071)

Ključne riječi

cefpodoxime proxetil; hydrolytic degradation; pH effect; voltammetry; UV-irradiation, darkness

Hrčak ID:

101909

URI

https://hrcak.srce.hr/101909

Datum izdavanja:

3.5.2013.

Posjeta: 2.579 *