Sažetak sa skupa
The Late-Effect Of X-Irradiation on the Mouse Submandibular Gland
M. Muhvić Urek
J. Tomac
S. Ćurić
J. Borčić
M. Bralić
R. Antonić
Sažetak
INTRODUCTION: Life-long severe xerostomia is a common complication after radiotherapy of head and neck malignancy. It is a clinical entity which causes a great deal of suffering and disability for the patient. Saliva is an important factor for denture retention. Hyposalivation causes reduced retention of full dentures. The aim of the study was to determine late consequences of irradiation in the mouse submandibular gland.
MATERIAL AND METHODS : Mouse submandibular glands were locally X-irradiated by single dose irradiation with 15Gy. Day 90 post-irradiation tissues were analyzed by morphology and morphometry.
RESULTS: Strong vacuolization of almost all acini was noted. Kariopyknotic nuclei were found in numerous acini and the largest amount of acini was in the lysis. The epithelial cells of the granular convoluted tubule were degenerated and desquamated in the lumen, and some granular convoluted tubules were in the lysis. In the interstitial connective tissue disseminated focal mononuclear
infiltrate was found. With respect to the control group a statistically significant decrease in the number of acinar cells (p<0.001) was determined, as well as a significant increase in the number of granular convoluted tubule cells (p<0.001). Whereas the number of intercalated duct cells was not different with respect to the control (p=0.10).
CONCLUSION: The results of this study suggest that hypofunction in the late stage is a consequence of morphological changes and loss of acinar cells. The patients should use a saliva substitute to alleviate their symptoms easier.
Ključne riječi
Hrčak ID:
10199
URI
Datum izdavanja:
15.9.2002.
Posjeta: 1.025 *