Izvorni znanstveni članak
Mitochondrial and Y-chromosomal profile of the Kazakh population from East Kazakhstan
Pavel V. Tarlykov
orcid.org/0000-0003-2075-307X
; National Center for Biotechnology of the Republic of Kazakhstan, Astana, Kazakhstan
Elena V. Zholdybayeva
; National Center for Biotechnology of the Republic of Kazakhstan, Astana, Kazakhstan
Ainur R. Akilzhanova
; National Center for Biotechnology of the Republic of Kazakhstan, Astana, Kazakhstan
Zhannur M. Nurkina
; National Center for Biotechnology of the Republic of Kazakhstan, Astana, Kazakhstan
Zhaxylyk M. Sabitov
; L.N. Gumilyov Eurasian National University, Astana, Kazakhstan
Tolebay K. Rakhypbekov
; Semey State Medical University Semey, Kazakhstan
Erlan M. Ramanculov
; National Center for Biotechnology of the Republic of Kazakhstan, Astana, Kazakhstan
Sažetak
Aim To study the genetic relationship of Kazakhs from East
Kazakhstan to other Eurasian populations by examining
paternal and maternal DNA lineages.
Methods Whole blood samples were collected in 2010
from 160 unrelated healthy Kazakhs residing in East Kazakhstan.
Genomic DNA was extracted with Wizard® genomic
DNA Purification Kit. Nucleotide sequence of hypervariable
segment I of mitochondrial DNA (mtDNA) was
determined and analyzed. Seventeen Y-short tandem repeat
(STR) loci were studied in 67 samples with the Amp-
FiSTR Y-filer PCR Amplification Kit. In addition, mtDNA data
for 2701 individuals and Y-STR data for 677 individuals were
retrieved from the literature for comparison.
Results There was a high degree of genetic differentiation
on the level of mitochondrial DNA. The majority of maternal
lineages belonged to haplogroups common in Central
Asia. In contrast, Y-STR data showed very low genetic diversity,
with the relative frequency of the predominant haplotype
of 0.612.
Conclusion The results revealed different migration patterns
in the population sample, showing there had been
more migration among women. mtDNA genetic diversity
in this population was equivalent to that in other Central
Asian populations. Genetic evidence suggests the existence
of a single paternal founder lineage in the population
of East Kazakhstan, which is consistent with verbal genealogical
data of the local tribes.
Ključne riječi
Hrčak ID:
102786
URI
Datum izdavanja:
15.2.2013.
Posjeta: 1.912 *