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The Novel Ketoprofenamides: Synthesis and Spectroscopic Characterization

Marijana Zovko ; Faculty of Pharmacy and Biochemistry, A. Kovačića 1, 10 000 Zagreb, Croatia
Branka Zorc   ORCID icon orcid.org/0000-0003-4355-8816 ; Faculty of Pharmacy and Biochemistry, A. Kovačića 1, 10 000 Zagreb, Croatia
Milena Jadrijević-Mladar Takač ; Faculty of Pharmacy and Biochemistry, A. Kovačića 1, 10 000 Zagreb, Croatia
Biserka Metelko ; PLIVA Pharm. Ind. Inc., Research Division, Prilaz baruna Filipovića 25, 10 000 Zagreb, Croatia
Predrag Novak ; PLIVA Pharm. Ind. Inc., Research Division, Prilaz baruna Filipovića 25, 10 000 Zagreb, Croatia

Puni tekst: engleski, pdf (149 KB) str. 335-341 preuzimanja: 819* citiraj
APA 6th Edition
Zovko, M., Zorc, B., Jadrijević-Mladar Takač, M., Metelko, B. i Novak, P. (2003). The Novel Ketoprofenamides: Synthesis and Spectroscopic Characterization. Croatica Chemica Acta, 76 (4), 335-341. Preuzeto s https://hrcak.srce.hr/103196
MLA 8th Edition
Zovko, Marijana, et al. "The Novel Ketoprofenamides: Synthesis and Spectroscopic Characterization." Croatica Chemica Acta, vol. 76, br. 4, 2003, str. 335-341. https://hrcak.srce.hr/103196. Citirano 23.11.2019.
Chicago 17th Edition
Zovko, Marijana, Branka Zorc, Milena Jadrijević-Mladar Takač, Biserka Metelko i Predrag Novak. "The Novel Ketoprofenamides: Synthesis and Spectroscopic Characterization." Croatica Chemica Acta 76, br. 4 (2003): 335-341. https://hrcak.srce.hr/103196
Harvard
Zovko, M., et al. (2003). 'The Novel Ketoprofenamides: Synthesis and Spectroscopic Characterization', Croatica Chemica Acta, 76(4), str. 335-341. Preuzeto s: https://hrcak.srce.hr/103196 (Datum pristupa: 23.11.2019.)
Vancouver
Zovko M, Zorc B, Jadrijević-Mladar Takač M, Metelko B, Novak P. The Novel Ketoprofenamides: Synthesis and Spectroscopic Characterization. Croatica Chemica Acta [Internet]. 2003 [pristupljeno 23.11.2019.];76(4):335-341. Dostupno na: https://hrcak.srce.hr/103196
IEEE
M. Zovko, B. Zorc, M. Jadrijević-Mladar Takač, B. Metelko i P. Novak, "The Novel Ketoprofenamides: Synthesis and Spectroscopic Characterization", Croatica Chemica Acta, vol.76, br. 4, str. 335-341, 2003. [Online]. Dostupno na: https://hrcak.srce.hr/103196. [Citirano: 23.11.2019.]

Sažetak
Synthesis of a series of new ketoprofenamides (3a-h) is described. Amide formation was achieved by aminolysis of ketoprofen benzotriazolide (2) with various amines: primary, secondary, hydroxylamine and amino acid β-alanine. The structures of synthesized compounds were characterized by means of IR, 1H and 13C NMR spectroscopies and elemental analysis. The synthesized compounds are potential prodrugs of a well-known NSAID ketoprofen.

Ključne riječi
ketoprofen; amide; benzotriazole; synthesis; FTIR and NMR spectroscopy

Hrčak ID: 103196

URI
https://hrcak.srce.hr/103196

Posjeta: 955 *