Croatica Chemica Acta, Vol. 76 No. 4, 2003.
Izvorni znanstveni članak
The Novel Ketoprofenamides: Synthesis and Spectroscopic Characterization
Marijana Zovko
; Faculty of Pharmacy and Biochemistry, A. Kovačića 1, 10 000 Zagreb, Croatia
Branka Zorc
orcid.org/0000-0003-4355-8816
; Faculty of Pharmacy and Biochemistry, A. Kovačića 1, 10 000 Zagreb, Croatia
Milena Jadrijević-Mladar Takač
; Faculty of Pharmacy and Biochemistry, A. Kovačića 1, 10 000 Zagreb, Croatia
Biserka Metelko
; PLIVA Pharm. Ind. Inc., Research Division, Prilaz baruna Filipovića 25, 10 000 Zagreb, Croatia
Predrag Novak
; PLIVA Pharm. Ind. Inc., Research Division, Prilaz baruna Filipovića 25, 10 000 Zagreb, Croatia
Sažetak
Synthesis of a series of new ketoprofenamides (3a-h) is described. Amide formation was achieved by aminolysis of ketoprofen benzotriazolide (2) with various amines: primary, secondary, hydroxylamine and amino acid β-alanine. The structures of synthesized compounds were characterized by means of IR, 1H and 13C NMR spectroscopies and elemental analysis. The synthesized compounds are potential prodrugs of a well-known NSAID ketoprofen.
Ključne riječi
ketoprofen; amide; benzotriazole; synthesis; FTIR and NMR spectroscopy
Hrčak ID:
103196
URI
Datum izdavanja:
28.11.2003.
Posjeta: 2.130 *