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The Novel Ketoprofenamides: Synthesis and Spectroscopic Characterization

Marijana Zovko ; Faculty of Pharmacy and Biochemistry, A. Kovačića 1, 10 000 Zagreb, Croatia
Branka Zorc orcid id orcid.org/0000-0003-4355-8816 ; Faculty of Pharmacy and Biochemistry, A. Kovačića 1, 10 000 Zagreb, Croatia
Milena Jadrijević-Mladar Takač ; Faculty of Pharmacy and Biochemistry, A. Kovačića 1, 10 000 Zagreb, Croatia
Biserka Metelko ; PLIVA Pharm. Ind. Inc., Research Division, Prilaz baruna Filipovića 25, 10 000 Zagreb, Croatia
Predrag Novak ; PLIVA Pharm. Ind. Inc., Research Division, Prilaz baruna Filipovića 25, 10 000 Zagreb, Croatia


Puni tekst: engleski pdf 149 Kb

str. 335-341

preuzimanja: 1.020

citiraj


Sažetak

Synthesis of a series of new ketoprofenamides (3a-h) is described. Amide formation was achieved by aminolysis of ketoprofen benzotriazolide (2) with various amines: primary, secondary, hydroxylamine and amino acid β-alanine. The structures of synthesized compounds were characterized by means of IR, 1H and 13C NMR spectroscopies and elemental analysis. The synthesized compounds are potential prodrugs of a well-known NSAID ketoprofen.

Ključne riječi

ketoprofen, amide, benzotriazole, synthesis, FTIR and NMR spectroscopy

Hrčak ID:

103196

URI

https://hrcak.srce.hr/103196

Posjeta: 1.376 *