Izvorni znanstveni članak

The Novel Ketoprofenamides: Synthesis and Spectroscopic Characterization

Marijana Zovko ; Faculty of Pharmacy and Biochemistry, A. Kovačića 1, 10 000 Zagreb, Croatia
Branka Zorc orcid.org/0000-0003-4355-8816 ; Faculty of Pharmacy and Biochemistry, A. Kovačića 1, 10 000 Zagreb, Croatia
Milena Jadrijević-Mladar Takač ; Faculty of Pharmacy and Biochemistry, A. Kovačića 1, 10 000 Zagreb, Croatia
Biserka Metelko ; PLIVA Pharm. Ind. Inc., Research Division, Prilaz baruna Filipovića 25, 10 000 Zagreb, Croatia
Predrag Novak ; PLIVA Pharm. Ind. Inc., Research Division, Prilaz baruna Filipovića 25, 10 000 Zagreb, Croatia

Sažetak

Synthesis of a series of new ketoprofenamides (3a-h) is described. Amide formation was achieved by aminolysis of ketoprofen benzotriazolide (2) with various amines: primary, secondary, hydroxylamine and amino acid β-alanine. The structures of synthesized compounds were characterized by means of IR, 1H and 13C NMR spectroscopies and elemental analysis. The synthesized compounds are potential prodrugs of a well-known NSAID ketoprofen.

Ključne riječi

ketoprofen; amide; benzotriazole; synthesis; FTIR and NMR spectroscopy

Hrčak ID:

103196

URI

https://hrcak.srce.hr/103196

Datum izdavanja:

28.11.2003.

Posjeta: 1.762 *