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SDRIFE (Baboon Syndrome) Due to Paracetamol: Case Report

Liboria Lugović-Mihić ; Department of DermatovenereologySestre milosrdnice University Hospital CenterVinogradska cesta 29HR-10000 ZagrebCroatia
Tomislav Duvančić
Majda Vučić
Mirna Šitum
Maja Kolić
Josip Mihić

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Sažetak
The term “baboon syndrome” (BS) (recently known as symmetrical
drug related intertriginous and flexural exanthema, SDRIFE)
was introduced in 1984 to describe a specific skin eruption (resembling
the red gluteal area of baboons) that occurred after systemic exposure
to contact allergens. The crucial characteristics include a sharply
defined symmetric erythema in the gluteal area and in the flexural or
intertriginous folds without any systemic symptoms or signs. Because
the term BS does not reflect the complete range of symptoms and
is ethically problematic, it was replaced with a new term of SDRIFE.
This term specifically refers to the distinctive clinical pattern of drug
eruption induced by exposure to a systemically administered drug,
presented as sharply demarcated symmetric erythematous areas of
the gluteal/perianal area and/or V-shaped erythema of the inguinal/
perigenital area (at least one other intertriginous/flexural localization)
and absence of systemic symptoms and signs. We present a case of a
33-year-old man with SDRIFE due to Panadol® tablets (paracematol).
On admission, there was a densely disseminated, symmetric, livid to
erythematous maculopapular exanthema present in both axillae, the
sides of the trunk, inguinally spreading towards the thighs, in cubital
and popliteal fossae, on the back sides of the upper legs, and in the
gluteal regions. Awareness of SDRIFE (BS) as an unusual drug reaction is
especially important since the connection between skin eruption and
drug exposure may easily be overlooked or misdiagnosed.

Ključne riječi
SDRIFE; baboon syndrome; drug eruption; systemic contact dermatitis; paracetamol

Hrčak ID: 106675

URI
https://hrcak.srce.hr/106675

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