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Patch Test Reactions to Metal Salts in Patients with Different Types of Dermatitis
; Department of Pharmacology Faculty of Pharmacy and Biochemistry University of Zagreb Domagojeva 2, 10000 Zagreb
Background: Metal allergies can be clinical problem, especially in atopic individuals. This study is unique and contributes with new knowledge in everyday life skin care of irritant and atopic dermatitis patients.
Objectives: The aim of the study was to determine the frequency of positive patch test reactions to metal contact allergens (potassium dichromate, cobalt chloride, nickel sulphate, white mercury precipitate) in patients diagnosed with allergic contact dermatitis, irritant contact dermatitis, and atopic dermatitis.
Patients and Methods: Between 2007 and 2011, patch testing was performed in 2185 patients according to International Contact Dermatitis Research Group technique.
Results: Study results showed statistically significant differences in patch test responses to 2 allergens, nickel sulphate (χ2 = 24.22; p < 0.001) and cobalt chloride (χ2 = 22.72; p < 0.001). Nickel sulphate was the most common allergen in allergic contact dermatitis and atopic dermatitis, while for irritant contact dermatitis the most common allergen was cobalt chloride. Among the 4 tested metal allergens the most common and relevant was nickel sulphate (χ2 = 17.25; p < 0.004), found in almost all examinees.
Conclusion: The increased awareness of allergens and their potential sources may help to limit the use of these chemicals in consumer product manufacturing.
Hrčak ID: 109925
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