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https://doi.org/10.2478/acph-2014-0003

GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD

IRENA ŽUNTAR   ORCID icon orcid.org/0000-0002-6793-6263 ; University of Zagreb, Faculty of Pharmacy Zagreb, Croatia
ROBERTA PETLEVSKI ; University of Zagreb, Faculty of Pharmacy Zagreb, Croatia
SLAVICA DODIG ; Children's Hospital Srebrnjak, Referral Centre for Clinical Paediatric Allergology of the Ministry of Health and Social Welfare, Zagreb, Croatia
SANJA POPOVIĆ-GRLE ; University Hospital for Pulmonary Diseases Jordanovac, Zagreb, Croatia

Puni tekst: engleski, pdf (190 KB) str. 117-129 preuzimanja: 524* citiraj
APA 6th Edition
ŽUNTAR, I., PETLEVSKI, R., DODIG, S. i POPOVIĆ-GRLE, S. (2014). GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD. Acta Pharmaceutica, 64 (1), 117-129. https://doi.org/10.2478/acph-2014-0003
MLA 8th Edition
ŽUNTAR, IRENA, et al. "GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD." Acta Pharmaceutica, vol. 64, br. 1, 2014, str. 117-129. https://doi.org/10.2478/acph-2014-0003. Citirano 19.09.2019.
Chicago 17th Edition
ŽUNTAR, IRENA, ROBERTA PETLEVSKI, SLAVICA DODIG i SANJA POPOVIĆ-GRLE. "GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD." Acta Pharmaceutica 64, br. 1 (2014): 117-129. https://doi.org/10.2478/acph-2014-0003
Harvard
ŽUNTAR, I., et al. (2014). 'GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD', Acta Pharmaceutica, 64(1), str. 117-129. https://doi.org/10.2478/acph-2014-0003
Vancouver
ŽUNTAR I, PETLEVSKI R, DODIG S, POPOVIĆ-GRLE S. GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD. Acta Pharm. [Internet]. 2014 [pristupljeno 19.09.2019.];64(1):117-129. https://doi.org/10.2478/acph-2014-0003
IEEE
I. ŽUNTAR, R. PETLEVSKI, S. DODIG i S. POPOVIĆ-GRLE, "GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD", Acta Pharmaceutica, vol.64, br. 1, str. 117-129, 2014. [Online]. https://doi.org/10.2478/acph-2014-0003

Sažetak
The aim of this study was to test the hypothesis that glutathione-S-transferase (GST) genotypes were associated with COPD. GSTP1, GSTM1 and GSTT1 genotypes were determined by DNA methods and GST activity spectrophotometrically in older male Caucasian Croats (non-smokers, ex-smokers, and smokers) with stable COPD (n = 30) and sex/age matched controls (n = 60). The distribution of GSTP1 genotypes and alleles in controls vs. COPD showed a statistical difference (p < 0.05). The odds ratio of CC/CT+TT (wild type GSTP1 exon 6 vs. joint heterozygous and mutant homozygous GSTP1 exon 6) was 10.000 and statistically different (p = 0.002). In this study, the GSTP1 mutant genotype of exon 5 (GG), as well as GSTP1 mutant and heterozygous genotypes of exon 6 (TT and CT), were suggested to be genetic contributors to COPD susceptibility. Null GSTM1, null GSTT1 and joint GSTM1/GSTT1 null genotypes were not disease associated. Serum GST was not associated with GST genotypes and COPD or smoking history in our study subjects. Conclusions drawn from the study should be further supported and clarified by studies with larger sample sizes.

Ključne riječi
glutathione S-transferases (GST); polymorphism; COPD; alpha-1- antitrypsin; lactate dehydrogenase

Hrčak ID: 113582

URI
https://hrcak.srce.hr/113582

Posjeta: 676 *