Izvorni znanstveni članak
Obesity and Systolic Blood Pressure in Young Adult Men Born Small for Gestational Age
Mario Laganović
orcid.org/0000-0002-0240-4178
; University of Zagreb, School of Medicine, Department for Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, Zagreb Croatia
Ivana Vuković Lela
; University of Zagreb, School of Medicine, Department for Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, Zagreb Croatia
Vedran Premužić
orcid.org/0000-0001-6264-6809
; University of Zagreb, School of Medicine, Department for Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, Zagreb Croatia
Sandra Karanović
orcid.org/0000-0003-2696-5305
; University of Zagreb, School of Medicine, Department for Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, Zagreb Croatia
Ana Vrdoljak
orcid.org/0000-0002-9262-4667
; University of Zagreb, School of Medicine, Department for Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, Zagreb Croatia
Bojan Jelaković
; University of Zagreb, School of Medicine, Department for Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, Zagreb Croatia
Sažetak
Individuals born small for gestational age (SGA) are supposed to be at higher risk to develop cardiovascular disorders,
and recent report showed that concurrent obesity influences blood pressure (BP) in SGA children. Our aim was to investi-
gate the impact of obesity and birth weight on blood pressure values in young adult men born SGA and controls born after
normal pregnancy, Normotensive, non-treated adult men were enrolled (N=185; mean age 21.29 ± 0.9 years). Birth para-
meters were obtained from medical records and SGA was defined as birth weight (BW) under 10th percentile for gestational
age and obesity as BMI >25 kg/m2. According to the presence or absence of obesity and BW the subjects were divided into
four groups: (1) non-obese with normal BW (N=50), (2) non-obese SGA (N=67), (3) obese with normal BW (N=40), (4)
obese SGA (N=28). BP was measured using Omron M6 and Spacelab 90207 device following the ESH/ESC guidelines.
Systolic BP 24-hour BP variability and pulse pressure were significantly higher in SGA subjects than in those with normal
,
BW (p<0.05). The highest 24-hour and daytime systolic BP values as well as 24-hour pulse pressure were found in the sub-
group of obese SGA subjects (p<0.001). Significant differences for the above parameters were observed between obese SGA
group and non-obese SGA group (p<0.05). Obese SGA subjects had higher 24-hour and daytime systolic BP values com-
pared to obese normal BW group. No difference was found in BP between non-obese SGA and non-obese group with normal
BW (p>0.05). In addition to BW and shorter pregnancy duration, obesity concurrently and significantly determines sys-
tolic BP in young normotensive men and point to a need for more agressive implementation of healthy lifestyle as early as
possible.
Ključne riječi
birth weight; small for gestational age; hypertension; obesity; young adult men
Hrčak ID:
118210
URI
Datum izdavanja:
30.9.2013.
Posjeta: 899 *