Izvorni znanstveni članak
Interleukin-6 Polymorphism and Prostate Cancer Risk in Population of Eastern Croatia
Sanja Mandić
; »J. J. Strossmayer« University, University Hospital Centre Osijek, Department of Clinical Laboratory Diagnostics, Osijek, Croatia
Bojan Sudarević
; »J. J. Strossmayer« University, University Hospital Centre Osijek, Clinic of Urology, Osijek, Croatia
Saška Marczi
; »J. J. Strossmayer« University, University Hospital Centre Osijek, Clinical Institute of Nuclear Medicine and Radiation Protection, Department of Molecular Diagnostics and Tissue Typing, Osijek, Croatia
Vesna Horvat
; »J. J. Strossmayer« University, University Hospital Centre Osijek, Department of Clinical Laboratory Diagnostics, Osijek, Croatia
Ivan Ćosić
; »J. J. Strossmayer« University, University Hospital Centre Osijek, Clinic of Urology, Osijek, Croatia
Slobodan Mihaljević
; University of Zagreb, University Hospital Centre Zagreb, Clinic of Gynecology and Obstetrics, Department for Anaesthesiology, Zagreb, Croatia
Nevenka Miličević
; »J. J. Strossmayer« University, University Hospital Centre Osijek, Department of Anesthesiology, Reanimatology and Intensive Care Unit, Osijek, Croatia
Dalibor Šimunović
; »J. J. Strossmayer« University, University Hospital Centre Osijek, Clinic of Urology, Osijek, Croatia
Josip Galić
; »J. J. Strossmayer« University, University Hospital Centre Osijek, Clinic of Urology, Osijek, Croatia
Sažetak
Recent studies suggest that chronic inflammation is crucial in the development and progression of prostate cancer (CaP). Interleukin-6 (IL-6) is a proinflammatory cytokine that plays an important role in intraprostatic inflammation and thus carcinogenesis. The –174G>C polymorphism of IL-6 gene has been associated with high IL-6 producer pheno- type and an increased risk for CaP . The aim of this study was to evaluate the association between the mentioned IL-6 polymorphism and CaP risk, as well as to compare the genotype frequency between the different tumour grades of CaP , in population of Eastern Croatia. We analyzed the IL-6 polymorphism in 120 CaP patients and 120 controls with benign prostatic hyperplasia (BPH). CaP patients and BPH controls did not statistically differ in studied IL-6 polymorphism. Furthermore, high IL-6 producer genotypes (GG or GC) were more frequent in controls than in CaP group (86.7% vs 80.8%, respectively, p=0.147). Also, no statistically significant difference in IL-6 high and low producer genotype fre- quency was noticed between well, moderately and poorly differentiated tumours. Our results, taken together with other studies on the subject, suggest that IL-6 – 174 single nucleotide polymorphism (SNP) distribution may differ between various ethnic groups and that a single cytokine gene polymorphism has probably just a minor effect on CaP susceptibil- ity. Further studies should be performed to clarify the link between SNPs of different cytokines and the risk for CaP .
Ključne riječi
prostate cancer; IL-6; SNPs; Croatia
Hrčak ID:
118292
URI
Datum izdavanja:
30.9.2013.
Posjeta: 1.876 *