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Assessment of Endothelial Dysfunction by Measuring Von Willebrand Factor and Exhaled Nitric Oxide in Patients with Chronic Obstructive Pulmonary Disease

Lana Maričić ; University »Josip Juraj Strossmayer«, University Hospital Centre Osijek, Department of Internal Medicine, Osijek, Croatia
Andrijana Včeva ; University »Josip Juraj Strossmayer«, University Hospital Centre Osijek, Department of Otorhinolaryngology, Head and Neck Surgery, Osijek, Croatia
Roberta Višević ; University »Josip Juraj Strossmayer«, University Hospital Centre Osijek, Department of Internal Medicine, Osijek, Croatia
Aleksandar Včev ; University »Josip Juraj Strossmayer«, University Hospital Centre Osijek, Department of Internal Medicine, Osijek, Croatia
Marija Milić ; University »Josip Juraj Strossmayer«, University Hospital Centre Osijek, Deparment of Clinical Laboratory Diagnostics, Osijek, Croatia
Vatroslav Šerić ; University »Josip Juraj Strossmayer«, University Hospital Centre Osijek, Deparment of Clinical Laboratory Diagnostics, Osijek, Croatia
Vladimir Fijačko ; University »Josip Juraj Strossmayer«, University Hospital Centre Osijek, Department of Internal Medicine, Osijek, Croatia

Puni tekst: engleski, pdf (103 KB) str. 1153-1160 preuzimanja: 196* citiraj
APA 6th Edition
Maričić, L., Včeva, A., Višević, R., Včev, A., Milić, M., Šerić, V. i Fijačko, V. (2013). Assessment of Endothelial Dysfunction by Measuring Von Willebrand Factor and Exhaled Nitric Oxide in Patients with Chronic Obstructive Pulmonary Disease. Collegium antropologicum, 37 (4), 1153-1160. Preuzeto s https://hrcak.srce.hr/118361
MLA 8th Edition
Maričić, Lana, et al. "Assessment of Endothelial Dysfunction by Measuring Von Willebrand Factor and Exhaled Nitric Oxide in Patients with Chronic Obstructive Pulmonary Disease." Collegium antropologicum, vol. 37, br. 4, 2013, str. 1153-1160. https://hrcak.srce.hr/118361. Citirano 27.02.2020.
Chicago 17th Edition
Maričić, Lana, Andrijana Včeva, Roberta Višević, Aleksandar Včev, Marija Milić, Vatroslav Šerić i Vladimir Fijačko. "Assessment of Endothelial Dysfunction by Measuring Von Willebrand Factor and Exhaled Nitric Oxide in Patients with Chronic Obstructive Pulmonary Disease." Collegium antropologicum 37, br. 4 (2013): 1153-1160. https://hrcak.srce.hr/118361
Harvard
Maričić, L., et al. (2013). 'Assessment of Endothelial Dysfunction by Measuring Von Willebrand Factor and Exhaled Nitric Oxide in Patients with Chronic Obstructive Pulmonary Disease', Collegium antropologicum, 37(4), str. 1153-1160. Preuzeto s: https://hrcak.srce.hr/118361 (Datum pristupa: 27.02.2020.)
Vancouver
Maričić L, Včeva A, Višević R, Včev A, Milić M, Šerić V i sur. Assessment of Endothelial Dysfunction by Measuring Von Willebrand Factor and Exhaled Nitric Oxide in Patients with Chronic Obstructive Pulmonary Disease. Collegium antropologicum [Internet]. 2013 [pristupljeno 27.02.2020.];37(4):1153-1160. Dostupno na: https://hrcak.srce.hr/118361
IEEE
L. Maričić, et al., "Assessment of Endothelial Dysfunction by Measuring Von Willebrand Factor and Exhaled Nitric Oxide in Patients with Chronic Obstructive Pulmonary Disease", Collegium antropologicum, vol.37, br. 4, str. 1153-1160, 2013. [Online]. Dostupno na: https://hrcak.srce.hr/118361. [Citirano: 27.02.2020.]

Sažetak
Chronic obstructive pulmonary disease (COPD) is a multisystemic disease, one of the leading causes of mortality and morbidity. The aim of this research is to assess the level of markers of endothelial dysfunction, vWf and the exhaled nitric oxide (NO) depending on the severity of COPD. The study included 100 subjects: 60 patients with COPD without adjoin- ing cardiovascular comorbidity, and 40 patients as the controls. The subjects underwent a fractional exhaled nitric oxide test (FeNO), spirometric testing, and diffusing capacity of the lung for carbon monoxide test (DLCO), samples were taken of their vein blood to analyze the level of vWf (using the vWf:RCO method), C-reactive protein (CRP), fibrinogen, choles- terol, triglycerides as well as the acid base status. COPD patients then filled COPD assessment test (CAT test) and the modified dyspnea scale (mMRC). The results showed that in patient group that higher levels of vWf are associated with lower values of exhaled NO, which means that higher levels of vWf are associated with lower values of exhaled NO. By comparing the ill subjects from four groups (A, B, C and D), a difference was established between the level of vWf [F (3.56 =0.24; p=0.869], while, although statistically not significant, the highest level of exhaled NO was found in group A and the lowest in group D. The rise in the value of vWf is followed by the rise of fibrinogen values, which is another marker of endothelial dysfunction. The results of this research have shown that a systemic inflammation and hypoxia in the early stages of COPD, when no significant changes in the absolute values of FEV1 are present, stipulate the existence of endo- thelial dysfunction together with the clinically relevant differences in the levels of vWf and exhaled NO.

Ključne riječi
COPD; endothelial dysfunction; nitric oxide; von Willenbrand factor; fibrinogen

Hrčak ID: 118361

URI
https://hrcak.srce.hr/118361

Posjeta: 335 *