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Original scientific paper
https://doi.org/10.5599/admet.2.1.33

The intrinsic aqueous solubility of indomethacin

John Comer ; Sirius Analytical Ltd., Forest Row, West Sussex RH18 5DW, UK
Sam Judge ; Sirius Analytical Ltd., Forest Row, West Sussex RH18 5DW, UK
Darren Matthews ; Sirius Analytical Ltd., Forest Row, West Sussex RH18 5DW, UK
Louise Towes ; Sirius Analytical Ltd., Forest Row, West Sussex RH18 5DW, UK
Bruno Falcone ; Unilever Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
Jonathan Goodman ; Unilever Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
John Dearden ; School of Pharmacy & Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, UK

Fulltext: english, pdf (915 KB) pages 18-32 downloads: 3.231* cite
APA 6th Edition
Comer, J., Judge, S., Matthews, D., Towes, L., Falcone, B., Goodman, J. & Dearden, J. (2014). The intrinsic aqueous solubility of indomethacin. ADMET and DMPK, 2 (1), 18-32. https://doi.org/10.5599/admet.2.1.33
MLA 8th Edition
Comer, John, et al. "The intrinsic aqueous solubility of indomethacin." ADMET and DMPK, vol. 2, no. 1, 2014, pp. 18-32. https://doi.org/10.5599/admet.2.1.33. Accessed 18 Sep. 2019.
Chicago 17th Edition
Comer, John, Sam Judge, Darren Matthews, Louise Towes, Bruno Falcone, Jonathan Goodman and John Dearden. "The intrinsic aqueous solubility of indomethacin." ADMET and DMPK 2, no. 1 (2014): 18-32. https://doi.org/10.5599/admet.2.1.33
Harvard
Comer, J., et al. (2014). 'The intrinsic aqueous solubility of indomethacin', ADMET and DMPK, 2(1), pp. 18-32. https://doi.org/10.5599/admet.2.1.33
Vancouver
Comer J, Judge S, Matthews D, Towes L, Falcone B, Goodman J, et al. The intrinsic aqueous solubility of indomethacin. ADMET and DMPK [Internet]. 2014 [cited 2019 September 18];2(1):18-32. https://doi.org/10.5599/admet.2.1.33
IEEE
J. Comer, et al., "The intrinsic aqueous solubility of indomethacin", ADMET and DMPK, vol.2, no. 1, pp. 18-32, 2014. [Online]. https://doi.org/10.5599/admet.2.1.33

Abstracts
A value of 8.8 μg/mL was measured for the intrinsic solubility of indomethacin. Evidence of a form with a solubility of about 77 μg/mL was also obtained. Solubility measurements were conducted using the CheqSol and Curve Fitting methods using a maximum pH of 9. It is also demonstrated that a published intrinsic solubility of 410 μg/mL was in error due to decomposition of indomethacin at pH 12. The decomposition of indomethacin at pH 12 was investigated. Decomposition products comprising p-chlorobenzoic acid and 5-Methoxy-2-methyl-3-indoleacetic acid were isolated and characterised.

Keywords
Indomethacin; solubility; CheqSol; p-chlorobenzoic acid; decomposition

Hrčak ID: 119017

URI
https://hrcak.srce.hr/119017

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