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https://doi.org/10.2478/10004-1254-65-2014-2461

Photochemical toxicity of drugs intended for ocular use

Roshan Kumar Sahu ; CSIR-Open Source Drug Discovery Unit, Council of Scientific and Industrial Research Anusandhan Bhawan, New Delhi, India
Bhupendra Singh ; Department of Pharmaceutical Sciences, School for Biosciences & Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, India
Shubhini A. Saraf ; Department of Pharmaceutical Sciences, School for Biosciences & Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, India
Gaurav Kaithwas ; Department of Pharmaceutical Sciences, School for Biosciences & Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, India
Kamal Kishor ; Indian Institute of Technology, Kanpur, India

Puni tekst: engleski, pdf (522 KB) str. 157-166 preuzimanja: 727* citiraj
APA 6th Edition
Sahu, R.K., Singh, B., Saraf, S.A., Kaithwas, G. i Kishor, K. (2014). Photochemical toxicity of drugs intended for ocular use. Arhiv za higijenu rada i toksikologiju, 65 (2), 157-166. https://doi.org/10.2478/10004-1254-65-2014-2461
MLA 8th Edition
Sahu, Roshan Kumar, et al. "Photochemical toxicity of drugs intended for ocular use." Arhiv za higijenu rada i toksikologiju, vol. 65, br. 2, 2014, str. 157-166. https://doi.org/10.2478/10004-1254-65-2014-2461. Citirano 15.04.2021.
Chicago 17th Edition
Sahu, Roshan Kumar, Bhupendra Singh, Shubhini A. Saraf, Gaurav Kaithwas i Kamal Kishor. "Photochemical toxicity of drugs intended for ocular use." Arhiv za higijenu rada i toksikologiju 65, br. 2 (2014): 157-166. https://doi.org/10.2478/10004-1254-65-2014-2461
Harvard
Sahu, R.K., et al. (2014). 'Photochemical toxicity of drugs intended for ocular use', Arhiv za higijenu rada i toksikologiju, 65(2), str. 157-166. https://doi.org/10.2478/10004-1254-65-2014-2461
Vancouver
Sahu RK, Singh B, Saraf SA, Kaithwas G, Kishor K. Photochemical toxicity of drugs intended for ocular use. Arh Hig Rada Toksikol. [Internet]. 2014 [pristupljeno 15.04.2021.];65(2):157-166. https://doi.org/10.2478/10004-1254-65-2014-2461
IEEE
R.K. Sahu, B. Singh, S.A. Saraf, G. Kaithwas i K. Kishor, "Photochemical toxicity of drugs intended for ocular use", Arhiv za higijenu rada i toksikologiju, vol.65, br. 2, str. 157-166, 2014. [Online]. https://doi.org/10.2478/10004-1254-65-2014-2461

Sažetak
The present investigation was undertaken to evaluate the possible ocular phototoxicity of drugs used in ophthalmic formulations. Sulphacetamide, ketoconazole, voriconazole, diclofenac, and ketorolac were assessed in the concentrations available in the market for their ocular use. The suitable models viz Hen’s Egg Test Chorioallantoic Membrane (HET-CAM) test, Isolated Chicken Eye (ICE) test, and Red Blood Cell (RBC) haemolysis test as recommended by ECVAM, ICCVAM, and OECD guidelines were performed. Results of HET-CAM and ICE tests suggest that sulphacetamide is moderately toxic in the presence of light/UV-A and very slightly irritant without irradiation. Ketoconazole and voriconazole were found slightly irritant in presence of light/UV-A and non-irritant in dark. Diclofenac and ketorolac demonstrated slight irritancy in the light and were found to be non-irritant in dark. The results suggest that some of the drugs have potential toxic effect in the presence of light. The extent of phototoxicity might get extended when used for longer time. The recommendation is that these drugs should be stored and used in the dark for a specified time and be labelled with specific instructions for patients, especially for those working longer in the sunlight.

Ključne riječi
antibacterial agents; antifungal agents; HET-CAM Test; ICE Test; NSAIDs; RBC Test

Hrčak ID: 122926

URI
https://hrcak.srce.hr/122926

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