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Human Papillomavirus-Related Diseases of the Female Lower Genital Tract: Oncogenic Aspects and Molecular Interaction

Joško Zekan ; University of Zagreb, University Hospital Center Zagreb, Department of Gynecology and Obstetrics, Zagreb, Croatia
Mihael Skerlev ; University of Zagreb, School of Medicine, Department of Dermatology and Venereology, Zagreb, Croatia
Lukrecija Milić ; University of Split, University Hospital Center Split, Department of Gynecology and Obstetrics, Split, Croatia
Deni Karelović ; University of Split, University Hospital Center Split, Department of Gynecology and Obstetrics, Split, Croatia

Puni tekst: engleski pdf 98 Kb

str. 779-786

preuzimanja: 623



The causal role of human papillomavirus (HPV) in all cancers of the uterine cervix has been firmly established biologically and epidemiologically. Most cancers of both the vulva and the vagina are also induced by HPV. Papillomaviruses are perfectly adapted to their natural host tissue, the differentiating epithelial cell of skin or mucosae, and exploit the cellular machinery for their own purposes. The infectious cycle is initiated once the infectious particles reach the basal layer of the epithelium, where they bind to and enter the cells. The critical molecules in the process of virus replication are the viral proteins E6 and E7, which interact with a number of cellular proteins. In experimental system these interactions have been shown to induce proliferation and eventually immortalization and malignant transformation of cells. Binding of E7 to pRb activates the E2F transcription factor, which then triggers the expression of proteins necessary for DNA replication. Unscheduled S-phase would normally lead to apoptosis by the action of p53. However, in HPV-infected cells, this process is counteracted by the viral E6 protein, which targets p53 for proteolytic degradation. Besides blocking p53 function in regulation of apoptosis, high-risk HPV proteins interact with both extrinsic and intrinsic apoptotic pathways. As an aberration of virus infection, constant activity of the viral proteins E6 and E7 leads to increasing genomic instability, accumulation of oncogene mutations, further loss of cell-growth control and ultimately cancer. The immune system uses innate and adaptive immunity to recognize and combat foreign agents that invade the body, but these methods are sometimes ineffective against human papillomavirus. HPV has several mechanisms for avoiding the immune system. Furthermore, HPV infections disrupt cytokine expression with the E6 and E7 oncoproteins, particularly targeting the expression of interferon genes. Approximately 10% of individuals develop a persistent infection, and it is this cohort who is at risk of cancer progression, with the development of high-grade precursor lesions and eventually invasive carcinoma.

Ključne riječi

human papillomavirus, early viral oncogenes, tumor suppressor genes, malignant transformation

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