Pregledni rad

https://doi.org/10.1515/acph-2015-0019

Virosome, a hybrid vehicle for efficient and safe drug delivery and its emerging application in cancer treatment

HANQING LIU ; School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, China
ZHIGANG TU ; Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China
FAN FENG ; Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China
HAIFENG SHI ; Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China
KEPING CHEN ; Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China
XIMING XU ; School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, China

Sažetak

A virosome is an innovative hybrid drug delivery system with advantages of both viral and non-viral vectors. Studies have shown that a virosome can carry various biologically active molecules, such as nucleic acids, peptides, proteins and small organic molecules. Targeted drug delivery using virosome-based systems can be achieved through surface modifications of virosomes. A number of virosome-based prophylactic and therapeutic products with high safety profiles are currently available in the market. Cancer treatment is a big battlefield for virosome-based drug delivery systems. This review provides an overview of the general concept, preparation procedures, working mechanisms, preclinical studies and clinical applications of virosomes in cancer treatment.

Ključne riječi

virosome; drug delivery system; cancer treatment; cancer vaccine

Hrčak ID:

128998

URI

https://hrcak.srce.hr/128998

Datum izdavanja:

30.6.2015.

Posjeta: 2.522 *