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Biological Applications of Fullerene Derivatives: A Brief Overview

Tatiana Da Ros ; Dipartimento di Scienze Farmaceutiche, Universita di Trieste, Piazzale Europa 1, 34127 Trieste, Italy
Giampiero Spalluto ; Dipartimento di Scienze Farmaceutiche, Universita di Trieste, Piazzale Europa 1, 34127 Trieste, Italy
Maurizio Prato ; Dipartimento di Scienze Farmaceutiche, Universita di Trieste, Piazzale Europa 1, 34127 Trieste, Italy

Puni tekst: engleski, pdf (347 KB) str. 743-755 preuzimanja: 477* citiraj
APA 6th Edition
Da Ros, T., Spalluto, G. i Prato, M. (2001). Biological Applications of Fullerene Derivatives: A Brief Overview. Croatica Chemica Acta, 74 (4), 743-755. Preuzeto s https://hrcak.srce.hr/131951
MLA 8th Edition
Da Ros, Tatiana, et al. "Biological Applications of Fullerene Derivatives: A Brief Overview." Croatica Chemica Acta, vol. 74, br. 4, 2001, str. 743-755. https://hrcak.srce.hr/131951. Citirano 13.11.2019.
Chicago 17th Edition
Da Ros, Tatiana, Giampiero Spalluto i Maurizio Prato. "Biological Applications of Fullerene Derivatives: A Brief Overview." Croatica Chemica Acta 74, br. 4 (2001): 743-755. https://hrcak.srce.hr/131951
Harvard
Da Ros, T., Spalluto, G., i Prato, M. (2001). 'Biological Applications of Fullerene Derivatives: A Brief Overview', Croatica Chemica Acta, 74(4), str. 743-755. Preuzeto s: https://hrcak.srce.hr/131951 (Datum pristupa: 13.11.2019.)
Vancouver
Da Ros T, Spalluto G, Prato M. Biological Applications of Fullerene Derivatives: A Brief Overview. Croatica Chemica Acta [Internet]. 2001 [pristupljeno 13.11.2019.];74(4):743-755. Dostupno na: https://hrcak.srce.hr/131951
IEEE
T. Da Ros, G. Spalluto i M. Prato, "Biological Applications of Fullerene Derivatives: A Brief Overview", Croatica Chemica Acta, vol.74, br. 4, str. 743-755, 2001. [Online]. Dostupno na: https://hrcak.srce.hr/131951. [Citirano: 13.11.2019.]

Sažetak
Starting soon after the production of fullerenes in 1990, many efforts have been devoted to the application of C60 and its derivatives. In fact, [60]fullerene possesses a variety of interesting biological properties, such as HIV-P inhibition, DNA photocleavage, neuroprotection, apoptosis, etc. Unfortunately, the low solubility in biological fluids limits the use of these compounds as new pharmacophores for structure-activity relationship studies in medicinal Chemistry. This article briefly summarizes recent studies on the functionalization of C60 aimed at increasing water solubility as well as the preliminary studies performed on biological targets. In particular, the HIV-P inhibition, DNA photocleavage and antibacterial activity are discussed.

Ključne riječi
anti-HIV agent; antibacterial agent; C60; DNA photocleavage; fullerene; fulleropyrrolidine

Hrčak ID: 131951

URI
https://hrcak.srce.hr/131951

Posjeta: 664 *