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Izvorni znanstveni članak
https://doi.org/10.2478/v10007-007-0026-4

A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations

PADMARAJAIAH NAGARAJA
SHAILENDRA D. NAIK
ASHWINEE KUMAR SHRESTHA
ANANTHARAMAN SHIVAKUMAR

Puni tekst: engleski, pdf (83 KB) str. 333-342 preuzimanja: 4.823* citiraj
APA 6th Edition
NAGARAJA, P., NAIK, S.D., SHRESTHA, A.K. i SHIVAKUMAR, A. (2007). A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations. Acta Pharmaceutica, 57 (3), 333-342. https://doi.org/10.2478/v10007-007-0026-4
MLA 8th Edition
NAGARAJA, PADMARAJAIAH, et al. "A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations." Acta Pharmaceutica, vol. 57, br. 3, 2007, str. 333-342. https://doi.org/10.2478/v10007-007-0026-4. Citirano 18.10.2019.
Chicago 17th Edition
NAGARAJA, PADMARAJAIAH, SHAILENDRA D. NAIK, ASHWINEE KUMAR SHRESTHA i ANANTHARAMAN SHIVAKUMAR. "A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations." Acta Pharmaceutica 57, br. 3 (2007): 333-342. https://doi.org/10.2478/v10007-007-0026-4
Harvard
NAGARAJA, P., et al. (2007). 'A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations', Acta Pharmaceutica, 57(3), str. 333-342. https://doi.org/10.2478/v10007-007-0026-4
Vancouver
NAGARAJA P, NAIK SD, SHRESTHA AK, SHIVAKUMAR A. A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations. Acta Pharm. [Internet]. 2007 [pristupljeno 18.10.2019.];57(3):333-342. https://doi.org/10.2478/v10007-007-0026-4
IEEE
P. NAGARAJA, S.D. NAIK, A.K. SHRESTHA i A. SHIVAKUMAR, "A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations", Acta Pharmaceutica, vol.57, br. 3, str. 333-342, 2007. [Online]. https://doi.org/10.2478/v10007-007-0026-4

Sažetak
A new, simple and sensitive spectrophotometric method for the determination of some sulfonamide drugs has been developed. The method is based on the diazotisation of sulfacetamide, sulfadiazine, sulfaguanidine, sulfamerazine, sulfamethazine, sulfamethoxazole and coupling with 8-hydroxyquinoline in alkaline media to yield red coloured products, with absorption maximum at 500 nm. The Beer’s law is obeyed from 0.17.0 µg mL1. The limits of quantification and limits of detection were 0.110.18 and 0.030.5 µg mL1, respectively. Intraday precision (RSD 0.10.5%) and accuracy (recovery 97.3100.8) of the developed method were evaluated. No interference was observed from common adjuvants. The method has been successfully applied to the assay of sulpha drug in the pharmaceutical formulations.

Ključne riječi
sulfonamide drugs; diazotisation; 8-hydroxyquinoline; spectrophotometry; pharmaceutical formulation

Hrčak ID: 13274

URI
https://hrcak.srce.hr/13274

[hrvatski]

Posjeta: 5.316 *