hrcak mascot   Srce   HID

Stručni rad

Hereditary angioedema type I in a female patient: a case report

INGRID PRKAČIN   ORCID icon orcid.org/0000-0002-5830-7131 ; Clinical Hospital Merkur, Ivana Zajca 19, Zagreb, Croatia
ANA BAN ; Clinical Hospital Merkur, Ivana Zajca 19, Zagreb, Croatia
GORDANA CAVRIĆ ; Intensive Care Unit, Merkur Clinical Hospital, Zagreb, Croatia
DUBRAVKA BARTOLEK HAMP ; Intensive Care Unit, Merkur Clinical Hospital, Zagreb, Croatia

Puni tekst: engleski, pdf (85 KB) str. 97-98 preuzimanja: 129* citiraj
APA 6th Edition
PRKAČIN, I., BAN, A., CAVRIĆ, G. i BARTOLEK HAMP, D. (2014). Hereditary angioedema type I in a female patient: a case report. Signa vitae, 9 (Suppl. 1), 97-98. Preuzeto s https://hrcak.srce.hr/134174
MLA 8th Edition
PRKAČIN, INGRID, et al. "Hereditary angioedema type I in a female patient: a case report." Signa vitae, vol. 9, br. Suppl. 1, 2014, str. 97-98. https://hrcak.srce.hr/134174. Citirano 19.07.2019.
Chicago 17th Edition
PRKAČIN, INGRID, ANA BAN, GORDANA CAVRIĆ i DUBRAVKA BARTOLEK HAMP. "Hereditary angioedema type I in a female patient: a case report." Signa vitae 9, br. Suppl. 1 (2014): 97-98. https://hrcak.srce.hr/134174
Harvard
PRKAČIN, I., et al. (2014). 'Hereditary angioedema type I in a female patient: a case report', Signa vitae, 9(Suppl. 1), str. 97-98. Preuzeto s: https://hrcak.srce.hr/134174 (Datum pristupa: 19.07.2019.)
Vancouver
PRKAČIN I, BAN A, CAVRIĆ G, BARTOLEK HAMP D. Hereditary angioedema type I in a female patient: a case report. Signa vitae [Internet]. 2014 [pristupljeno 19.07.2019.];9(Suppl. 1):97-98. Dostupno na: https://hrcak.srce.hr/134174
IEEE
I. PRKAČIN, A. BAN, G. CAVRIĆ i D. BARTOLEK HAMP, "Hereditary angioedema type I in a female patient: a case report", Signa vitae, vol.9, br. Suppl. 1, str. 97-98, 2014. [Online]. Dostupno na: https://hrcak.srce.hr/134174. [Citirano: 19.07.2019.]

Sažetak
Hereditary angioedema (HAE) is rare autosomal dominant disease, characterised by spontaneous and recurrent swellings
in various parts of the body. The main inflammatory factor in HAE is bradykinin (a key mediator of non-allergic angioedema)
and it is responsible for capillary leak. C1 esterase inhibitor (C1-INH) is a protease inhibitor that blocks the activation of the
classic complement pathway, but there are also many others biochemical pathways, including kinin. Type I HAE is defined
by low plasma levels of a normal C1 inhibitor (C1-INH).
Case presentation. A 34-year-old female patient presented to the hospital complained of swollen and painful legs, flatulence,
palpebral and labial edema, dyspnea, dysuria, frequent herpetic infections of mouth and nose, subfebrile body temperature
and was hoarse. Over the last 20 years she suffered from occasional edemas of the extremities and abdomen. Laboratory
testing showed a reduced level of C1-INH, and with other test results normal we diagnosed the patient with HAE type I. For
emergency situations, we prescribed icatibant (B2 bradykinin receptor antagonist) subcutaneously.
Individuals with HAE report episodic attacks during childhood that become more severe during adolescence. There is nonpitting
edema in 3 predisposed places : subcutaneous tissue, the abdomen and the larynx. Edemas amplify during 12-24
hours and disappear during 3-5 days, with migrations to other locations. Treatment can be prophylactic, for acute attacks
(icatibant) and before medical treatments.
HAE is a potentially lethal disease and should be considered if repeating edema of various body parts, painful swelling and
tightening of the skin are present.

Ključne riječi
hereditary angioedema; bradykinin; B2 bradykinin receptor antagonist

Hrčak ID: 134174

URI
https://hrcak.srce.hr/134174

Posjeta: 219 *