Stručni rad

Multiple myeloma presenting with lower extremity gangrene and hyperviscosity syndrome

MARIJANA GRGIĆ MEDIĆ ; Division of Intensive Care Medicine, Department of Internal Medicine, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia
ANA VUJAKLIJA BRAJKOVIĆ ; Division of Intensive Care Medicine, Department of Internal Medicine, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia
IVAN GORNIK ; Division of Intensive Care Medicine, Department of Internal Medicine, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia
JAKŠA BABEL ; Division of Intensive Care Medicine, Department of Internal Medicine, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia
VLADIMIR GAŠPAROVIĆ ; Division of Intensive Care Medicine, Department of Internal Medicine, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia
DUBRAVKA BOSNIĆ ; Department of Immunology and Clinical Rheumatology, University Hospital Centre Zagreb, Croatia

Sažetak

Hyperviscosity syndrome and cryoblobulinemia associated with lymphoproliferative disorder is a rare but life threatening
condition. The delay of diagnosis can lead to severe mutilation and multiple organ damage. The plasma exchange therapy
and the targeted treatment of the underlying disorder can lead to significant improvement. We present a patient who
developed extensive soft tissue necroses, mimicking the peripheral artery disease. Despite surgical treatment, the skin
lesions progressed involving fingers, earlobes and scrotum. Finally, the patient was diagnosed with multiple myeloma and
hyperviscosity syndrome. The clinical condition improved after plasma exchange and myeloma treatment with thalidomide
and dexamethasone.

Ključne riječi

multiple myeloma; hyperviscosity; skin necrosis

Hrčak ID:

134175

URI

https://hrcak.srce.hr/134175

Datum izdavanja:

1.6.2014.

Posjeta: 1.244 *