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A Study of the Silicon and Aluminium Interaction with Cerebrospinal Fluid Proteins

Milica Trbojević-Čepe ; Institute of Clinical Laboratory Diagnostics, Clinical Hospital Center, Rebro, HR-10 000 Zagreb, Croatia
Halka Bilìnski ; Rudjer Bošković Institute, P. O. Box 1016, HR-10 000 Zagreb, Croatia
László Horváth ; Rudjer Bošković Institute, P. O. Box 1016, HR-10 000 Zagreb, Croatia


Puni tekst: engleski pdf 23.088 Kb

str. 543-557

preuzimanja: 271

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Sažetak

A precipitation experiment was performed with human cerebrospinal fluid (CSF) by adding to it aluminium and/or silicate ions. The aim was to elucidate their possible role in extracellular protein aggregation. Three quite different pathological conditions were simulated, such as predominance of A1 (as in renal failure), predominance of Si (as in silicosis), and coexistence of A1 and Si (as in Alzheimer's disease). In all cases, precipitates formed immediately, decreasing IgG (up to 34%) and lowering the albumin content in CSF in the order silicate » aluminium > aluminosilicate. Corresponding quantities of these proteins were not found in the water soluble proteinaceous part of precipitates, suggesting that they are firmly embedded in inorganic matrices identified by FTIR.

Ključne riječi

Hrčak ID:

136714

URI

https://hrcak.srce.hr/136714

Posjeta: 457 *