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Rad Hrvatske akademije znanosti i umjetnosti : Medicinske znanosti, No. 522=41, 2015.

Pregledni rad

Molecular stratification of colorectal cancer

Sanja Kapitanović   ORCID icon orcid.org/0000-0001-8788-3085

Puni tekst: engleski, pdf (422 KB) str. 107-115 preuzimanja: 188* citiraj
APA 6th Edition
Kapitanović, S. (2015). Molecular stratification of colorectal cancer. Rad Hrvatske akademije znanosti i umjetnosti, (522=41), 107-115. Preuzeto s https://hrcak.srce.hr/139036
MLA 8th Edition
Kapitanović, Sanja. "Molecular stratification of colorectal cancer." Rad Hrvatske akademije znanosti i umjetnosti, vol. , br. 522=41, 2015, str. 107-115. https://hrcak.srce.hr/139036. Citirano 23.04.2019.
Chicago 17th Edition
Kapitanović, Sanja. "Molecular stratification of colorectal cancer." Rad Hrvatske akademije znanosti i umjetnosti , br. 522=41 (2015): 107-115. https://hrcak.srce.hr/139036
Harvard
Kapitanović, S. (2015). 'Molecular stratification of colorectal cancer', Rad Hrvatske akademije znanosti i umjetnosti, (522=41), str. 107-115. Preuzeto s: https://hrcak.srce.hr/139036 (Datum pristupa: 23.04.2019.)
Vancouver
Kapitanović S. Molecular stratification of colorectal cancer. Rad Hrvatske akademije znanosti i umjetnosti [Internet]. 2015 [pristupljeno 23.04.2019.];(522=41):107-115. Dostupno na: https://hrcak.srce.hr/139036
IEEE
S. Kapitanović, "Molecular stratification of colorectal cancer", Rad Hrvatske akademije znanosti i umjetnosti, vol., br. 522=41, str. 107-115, 2015. [Online]. Dostupno na: https://hrcak.srce.hr/139036. [Citirano: 23.04.2019.]

Sažetak
Colorectal cancer (CRC) is one of the most common cancers and one of the leading causes of cancer death in the Western world. The disease arises from the accumulation of mutations in oncogenes, tumor suppressor genes and mismatch repair genes during progression from normal colon epithelium to adenoma and metastatic carcinoma. Improved understanding of genetic events that underline tumor development and progression may contribute to new strategies for prevention, diagnosis as well as for therapy. The results of Human genome project showed that each person has its unique genetic “signature” as a consequence of a large number of inherited genetic variations. There are also sporadic molecular changes specific for each tumor type. This mini review will give some information about the most frequent molecular genetics changes in colorectal cancer and its molecular stratification due to its heredity, germline pharmacogenetic markers, somatic mutations and microsatellite instability.

Ključne riječi
colorectal cancer; biomarkers; molecular stratification

Hrčak ID: 139036

URI
https://hrcak.srce.hr/139036

[hrvatski]

Posjeta: 301 *