Izvorni znanstveni članak

https://doi.org/10.11613/BM.2015.011

Increased plasma vaspin concentration in patients with sepsis: an exploratory examination

Michael C. Motal ; Department of Anaesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Vienna, Austria
Daniel A. Klaus ; Department of Anaesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Vienna, Austria
Diana Lebherz-Eichinger ; Department of Anaesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Vienna, Austria
Bianca Tudor ; Department of Anaesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Vienna, Austria
Thomas Hamp ; Department of Anaesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Vienna, Austria
Marion Wiegele ; Department of Anaesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Vienna, Austria
Rudolf Seemann ; Department of Cranio-, Maxillofacial and Oral Surgery, Medical University of Vienna, Vienna, Austria
Claus G. Krenn ; Department of Anaesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Vienna, Austria
Georg A. Roth ; Department of Anaesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Vienna, Austria

Sažetak

Introduction: Vaspin (visceral adipose tissue-derived serpin) was first described as an insulin-sensitizing adipose tissue hormone. Recently its anti-inflammatory function has been demonstrated. Since no appropriate data is available yet, we sought to investigate the plasma concentrations of vaspin in sepsis.
Materials and methods: 57 patients in intensive care, fulfilling the ACCP/SCCM criteria for sepsis, were prospectively included in our exploratory study. The control group consisted of 48 critically ill patients, receiving intensive care after trauma or major surgery. Patients were matched by age, sex, weight and existence of diabetes before statistical analysis. Blood samples were collected on the day of diagnosis. Vaspin plasma concentrations were measured using a commercially available enzyme-linked immunosorbent assay.
Results: Vaspin concentrations were significantly higher in septic patients compared to the control group (0.3 (0.1-0.4) ng/mL vs. 0.1 (0.0-0.3) ng/mL, respectively; P < 0.001). Vaspin concentration showed weak positive correlation with concentration of C-reactive protein (CRP) (r = 0.31, P = 0.002) as well as with SAPS II (r = 0.34, P = 0.002) and maximum of SOFA (r = 0.39, P < 0.001) scoring systems, as tested for the overall study population.
Conclusion: In the sepsis group, vaspin plasma concentration was about three-fold as high as in the median surgical control group. We demonstrated a weak positive correlation between vaspin and CRP concentration, as well as with two scoring systems commonly used in intensive care settings. Although there seems to be some connection between vaspin and inflammation, its role in human sepsis needs to be evaluated further.

Ključne riječi

adipocytokine; inflammation; vaspin; CRP; intensive care

Hrčak ID:

139263

URI

https://hrcak.srce.hr/139263

Datum izdavanja:

15.2.2015.

Posjeta: 1.208 *