Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2015.56.94
Prenatal dietary load of Maillard reaction products combined with postnatal Coca-Cola drinking affects metabolic status of female Wistar rats
Radana Gurecká
; Institute of Molecular Biomedicin Faculty of Medicine, Comenius University, Bratislava, Slovakia
Ivana Koborová
; Institute of Molecular Biomedicin Faculty of Medicine, Comenius University, Bratislava, Slovakia
Katarína Janšáková
; Institute of Molecular Biomedicin Faculty of Medicine, Comenius University, Bratislava, Slovakia
Tamás Tábi
; Department of Pharmacodynamics, Faculty ofPharmacy, Semmelweis University Budapest, Hungary
Éva Szökő
; Department of Pharmacodynamics, Faculty ofPharmacy, Semmelweis University Budapest, Hungary
Veronika Somoza
; Department of Nutritional and Physiological Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria
Katarína Šebeková
; Institute of Molecular Biomedicin Faculty of Medicine, Comenius University, Bratislava, Slovakia
Peter Celec
; Institute of Molecular Biomedicin Faculty of Medicine, Comenius University, Bratislava, Slovakia
Sažetak
Aim To assess the impact of prenatal exposure to Maillard
reaction products (MRPs) -rich diet and postnatal Coca-
Cola consumption on metabolic status of female rats.
Diet rich in MRPs and consumption of saccharose/fructose
sweetened soft drinks is presumed to impose increased
risk of development of cardiometabolic afflictions, such as
obesity or insulin resistance.
Methods At the first day of pregnancy, 9 female Wistar
rats were randomized into two groups, pair-fed either with
standard rat chow (MRP-) or MRPs-rich diet (MRP+). Offspring
from each group of mothers was divided into two
groups and given either water (Cola-) or Coca-Cola (Cola+)
for drinking ad libitum for 18 days. Oral glucose tolerance
test was performed, and circulating markers of inflammation,
oxidative stress, glucose and lipid metabolism were
assessed.
Results MRP+ groups had higher weight gain, significantly
so in the MRP+/Cola- vs MRP-/Cola-. Both prenatal
and postnatal intervention increased carboxymethyllysine
levels and semicarbazide-sensitive amine oxidase
activity, both significantly higher in MRP+/Cola + than in
MRP-/Cola-. Total antioxidant capacity was lower in MRP+
groups, with significant decrease in MRP+/Cola + vs MRP-/
Cola+. Rats drinking Coca-Cola had higher insulin, homeostatic
model assessment of insulin resistance, heart rate,
advanced oxidation of protein products, triacylglycerols,
and oxidative stress markers measured as thiobarbituric
acid reactive substances compared to rats drinking water,
with no visible effect of MRPs-rich diet.
Conclusion Metabolic status of rats was affected both by
prenatal and postnatal dietary intervention. Our results
suggest that combined effect of prenatal MRPs load and
postnatal Coca-Cola drinking may play a role in development
of metabolic disorders in later life.
Ključne riječi
Hrčak ID:
139300
URI
Datum izdavanja:
15.4.2015.
Posjeta: 1.538 *