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https://doi.org/10.1515/aiht-2015-66-2624

ADHD-like behaviour in the offspring of female rats exposed to low chlorpyrifos doses before pregnancy

Sofia Grabovska ; Institute of Animal Biology NAAS, Lviv, Ukraine
Yuriу Salyha ; Institute of Animal Biology NAAS, Lviv, Ukraine

Puni tekst: engleski, pdf (762 KB) str. 121-127 preuzimanja: 255* citiraj
APA 6th Edition
Grabovska, S. i Salyha, Y. (2015). ADHD-like behaviour in the offspring of female rats exposed to low chlorpyrifos doses before pregnancy. Arhiv za higijenu rada i toksikologiju, 66 (2), 121-127. https://doi.org/10.1515/aiht-2015-66-2624
MLA 8th Edition
Grabovska, Sofia i Yuriу Salyha. "ADHD-like behaviour in the offspring of female rats exposed to low chlorpyrifos doses before pregnancy." Arhiv za higijenu rada i toksikologiju, vol. 66, br. 2, 2015, str. 121-127. https://doi.org/10.1515/aiht-2015-66-2624. Citirano 11.08.2020.
Chicago 17th Edition
Grabovska, Sofia i Yuriу Salyha. "ADHD-like behaviour in the offspring of female rats exposed to low chlorpyrifos doses before pregnancy." Arhiv za higijenu rada i toksikologiju 66, br. 2 (2015): 121-127. https://doi.org/10.1515/aiht-2015-66-2624
Harvard
Grabovska, S., i Salyha, Y. (2015). 'ADHD-like behaviour in the offspring of female rats exposed to low chlorpyrifos doses before pregnancy', Arhiv za higijenu rada i toksikologiju, 66(2), str. 121-127. https://doi.org/10.1515/aiht-2015-66-2624
Vancouver
Grabovska S, Salyha Y. ADHD-like behaviour in the offspring of female rats exposed to low chlorpyrifos doses before pregnancy. Arh Hig Rada Toksikol. [Internet]. 2015 [pristupljeno 11.08.2020.];66(2):121-127. https://doi.org/10.1515/aiht-2015-66-2624
IEEE
S. Grabovska i Y. Salyha, "ADHD-like behaviour in the offspring of female rats exposed to low chlorpyrifos doses before pregnancy", Arhiv za higijenu rada i toksikologiju, vol.66, br. 2, str. 121-127, 2015. [Online]. https://doi.org/10.1515/aiht-2015-66-2624

Sažetak
The aim of this study was to investigate how chronic low-dose chlorpyrifos exposure of female Wistar rats before and during pregnancy affects behavioural parameters in their offspring. Four months before pregnancy, we exposed three groups of rats to chlorpyrifos doses of 5, 10, and 15 mg kg-1 body weight every day for 30 days, whereas one group received a single 30 mg kg-1 dose on gestational day 6. When the offspring of the exposed rats grew up, we studied their anxiety rate, motor activity, and cognitive abilities using the respective behavioural tests: open field test, dark/light box, and the extrapolation escape test. The offspring of rats exposed before pregnancy had significantly higher activity rate than controls, and even showed motor agitation and hyperactivity signs. The offspring of rats exposed to the single dose had difficulties solving the extrapolation escape test and showed poorer short- and long-term memory performance. This confirmed that even pre-pregnancy chlorpyrifos exposure can cause neurobehavioral consequences in offspring. Even though the mechanisms of the observed changes remain unclear and need further investigation, these data seem alarming and may serve as an important argument for revising the terms of safe pesticide use.

Ključne riječi
neurotoxicity; organophosphate pesticides; anxiety; memory; motor activity

Hrčak ID: 139885

URI
https://hrcak.srce.hr/139885

[hrvatski]

Posjeta: 440 *