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The acute effect of the antioxidant drug "U-74389G" on mean corpuscular hemoglobin levels during hypoxia reoxygenation injury in rats

Constantinos Tsompos ; Mesologi County Hospital, Department of obstetrics & gynecology, Etolakarnania, Greece
Constantinos Panoulis ; Aretaieion Hospital, Department of obstetrics & gynecology, Athens University, Atiiki, Greece
Konstantinos Toutouzas ; Ipokrateion General Hospital, Department of surgery, Athens University, Atiiki Greece
George Zografos ; Ipokrateion General Hospital, Department of surgery, Athens University, Atiiki Greece
Apostolos Papalois ; Experimental research center ELPEN Pharmaceuticals, S.A.Inc., Co.


Puni tekst: engleski pdf 374 Kb

str. 17-24

preuzimanja: 312

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Sažetak

Aim: The aim of this experimental study was to examine the effect of the antioxidant drug “U-74389G”, on rat model and particularly in a hypoxia – reoxygenation protocol. The beneficial effect or non-effectiveness of that molecule was studied hematologically using blood mean corpuscular hemoglobin (MCH) levels.
Methods: 40 rats of mean weight 231.875 gr were used in the study. MCH levels were measured 60 min after reperfusion (groups A and C) and 120 min after reperfusion (groups B and D) with the administration of drug U-74389G in groups C and D.
Results: The results were that U-74389G administration significantly increased the MCH levels by 2.40% ± 0.57% (p = 0.0001). Reoxygenation time non-significantly decreased the MCH levels by 0.48% ± 0.69 (p = 0.4103). However, U-74389G administration and reoxygenation time together significantly increased the MCH levels by 1.33% ± 0.36% (p = 0.0005).
Conclusion: The results of this study indicate that U-74389G administration either alone or interacted with reoxygenation time has significant increasing short – term effects on the pathophysiology recovery of MCH values.

Ključne riječi

hypoxia, U-74389G; meann corpuscular hemoglobin levels; reperfusion

Hrčak ID:

143624

URI

https://hrcak.srce.hr/143624

Datum izdavanja:

17.8.2015.

Podaci na drugim jezicima: hrvatski

Posjeta: 954 *