Acta clinica Croatica, Vol. 43 No. 1, 2004.
Recenzija, Prikaz slučaja
Reactive and Clonal Thrombocytosis: Cytokines and Acute Phase Reactants
Ljiljana Fodor-Alagić
Vladimir Stančić
Petar Gaćina
Dubravka Čaržavec
Vjeran Nikolić-Heitzler
Danijel Planinc
Krešimir Štambuk
Ivan Bonić
Boris Car
Miljenko Solter
Mira Vitezić-Misjak
Branko Bečejac
Velimir Altabas
Sažetak
Platelets are acute phase reactants that increase in response to various stimuli, including systemic infections, inflammatory conditions, bleeding, and tumors. This is called reactive or secondary thrombocytosis, which is a benign form of thrombocytosis. Clonal thrombocytosis is an unregulated abnormality of platelet production due to clonal expansion of bone marrow progenitor cells. Secondary thrombocytosis may be due to the overproduction of proinflammatory cytokines such as interleukin-1 (IL-1), IL-6, and IL-11, which occurs in chronic inflammatory, infectious and malignant states. The presence of elevated IL-1, IL-6, C-reactive protein and granulocyte-macrophage colony-stimulating factor in individuals with this condition suggests that these cytokines may be involved in reactive thrombocytosis.
Ključne riječi
Thrombocytosis - classification; Thrombocytosis - etiology; Thrombocytosis - blood; Thrombocytosis - diagnosis
Hrčak ID:
14449
URI
Datum izdavanja:
1.3.2004.
Posjeta: 3.808 *