Acta clinica Croatica, Vol. 42 No. 1, 2003.
Professional paper
Inhaled Corticosteroids and the Risk of Glaucoma and Intraocular Hypertension
Katia Novak-Lauš
Suzana Kukulj
Renata Iveković
Eugenia Tedeschi-Reineo
Jadranka Koršić
Dubravka Matanić
Abstract
The aim of this study was to examine whether any correlation exists between long term use of high doses of inhaled corticosteroids and the occurrence of intraocular hypertension or open angle glaucoma. The study included 30 patients with bronchial asthma, treated with long term high doses of inhaled corticosteroids, and a control group of 30 age-matched healthy subjects. Apart from family history, the clinical examination included ophthalmologic examination, measurement of intraocular pressure, automated perimetry and photography of the optic nerve head. At least two of the following parameters were required for the diagnosis of glaucoma: intraocular pressure level, visual field defects, and characteristic appearance of the optic nerve head. The level of intraocular pressure (without therapy from 22 to 30 mmHg, daily pressure curve) was a criterion for the diagnosis of intraocular hypertension. In glaucoma free subjects, all parameters were within the normal limits. The study pointed to a correlation between long term use of high doses of inhaled corticosteroids and the occurrence of intraocular hypertension in patients with a positive family history of glaucoma.
Keywords
Anti-inflammatory agents - steroidal, adverse effects; Glaucoma, therapy; Intraocular pressure, drug effects
Hrčak ID:
14581
URI
Publication date:
3.3.2003.
Visits: 2.125 *