Acta clinica Croatica, Vol. 41 No. 3, 2002.
Izvorni znanstveni članak
Relationship between Red Cell Deformability and Shear Stress in Conditions of Low Shear Rate in Vascular Dementia
Piotr Kowal
Renata Modestowicw
Sažetak
The aim of the study was to evaluate the effect of shear stress connected with low shear rate on red blood cell deformability in chronic brain ischemia. The study was carried out in a group of 18 patients with vascular dementia and control group of ten healthy subjects. Shear stress was calculated as a function of blood viscosity and basic shear stress for the applied range of shear rate. Red cell deformability (red cell transit time, RCTT) was investigated by filtration method, and the level of fibrinogen was assessed by use of a Chromotimer device. Then the relationship of particular shear stress with RCTT and fibrinogen was analyzed. In comparison to the control group, patients with vascular dementia showed higher levels of RCTT (p<0.05) and fibrinogen (p<0.01). Statistically significant correlations between RCTT and shear stress at a shear rate of 3.23 s-1 (p<0.02) and 0.695 s-1 (p<0.05) were found in the group of patients with vascular dementia. Results of the study suggested that in the group of patients with vascular dementia, shear stress in the range of low shear rate considerably affected the RBC membrane, thus contributing to impairment of its elasticity.
Ključne riječi
Dementia - physiology; Cerebrovascular disorders - blood; Blood viscosity - physiology; Erythrocyte deformability - physiology
Hrčak ID:
14734
URI
Datum izdavanja:
2.9.2002.
Posjeta: 2.054 *