Croatica Chemica Acta, Vol. 88 No. 3, 2015.
Izvorni znanstveni članak
https://doi.org/10.5562/cca2725
Metal-Binding Ability of Leu-Enkephalin, Related Glycoconjugates and Peptidomimetics
Zsuzsa Majer
; Eötvös Loránd University, Institute of Chemistry, Laboratory for Chiroptical Structure Analysis, Pázmány Péter sétány 1/A, H-1117, Budapest, Hungary
Elemér Vass
; Eötvös Loránd University, Institute of Chemistry, Laboratory for Chiroptical Structure Analysis, Pázmány Péter sétány 1/A, H-1117, Budapest, Hungary
Maja Roščić
; Ruđer Bošković Institute, Division of Organic Chemistry and Biochemistry, Bijenička c. 54, HR-10000 Zagreb, Croatia
Miklós Hollósi
; Eötvös Loránd University, Institute of Chemistry, Laboratory for Chiroptical Structure Analysis, Pázmány Péter sétány 1/A, H-1117, Budapest, Hungary
Štefica Horvat
; Ruđer Bošković Institute, Division of Organic Chemistry and Biochemistry, Bijenička c. 54, HR-10000 Zagreb, Croatia
Andreja Jakas
; Ruđer Bošković Institute, Division of Organic Chemistry and Biochemistry, Bijenička c. 54, HR-10000 Zagreb, Croatia
Sažetak
Both the chemistry and consequences of the nonenzymatic reaction between reducing sugars and reactive amino groups of amino acids, peptides and proteins (known as the Maillard reaction), have received considerable attention in food and health science fields. This initial reaction results in Amadori and similar products formation, followed by degradation to advanced glycation end products (AGEs). It is well established that AGEs are associated with color and odor of thermally processed or stored food, as well as with pathogen products in a number of diseases. The model systems of early stage Maillard reaction products (MRP) were prepared between endogenous opioid peptide leucine enkephalin (1) and D-glucose / D-glucuronic acid. The complexation ability of prepared MRP with metal ions (Ca2+, Zn2+, Al3+, Pb2+ and Cu2+) was investigated and compared to the complexation ability of parent peptide using ECD and FTIR spectroscopic measurements.
Ključne riječi
Amadori compound; hydroxypyridinium; imidazolidinone; Maillard reaction; metal complex
Hrčak ID:
150533
URI
Datum izdavanja:
30.12.2015.
Posjeta: 2.068 *