Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2015.56.334
Red blood cell distribution width as a simple negative prognostic factor in patients with diffuse large B-cell lymphoma: a retrospective study
Vlatka Periša
orcid.org/0000-0003-4801-1270
; Department of Hematology, Clinic of Internal Medicine, University Hospital Centre Osijek, Osijek, Croatia
Lada Zibar
; University Josip Juraj Strossmayer in Osijek, School of Medicine, Osijek, Croatia
Jasminka Sinčić-Petričević
; Department of Hematology, Clinic of Internal Medicine, University Hospital Centre Osijek, Osijek, Croatia
Ana Knezović
; Community Health Centre Đakovo Đakovo, Croatia
Igor Periša
; Community Health Centre Vinkovci, Vinkovci, Croatia
Jerko Barbić
; University Josip Juraj Strossmayer in Osijek, School of Medicine, Osijek, Croatia
Sažetak
Aim To determine the prognostic value of baseline red
blood cell distribution width (RDW) in diffuse large B cell
lymphoma (DLBCL) patients.
Methods Data from 81 DLBCL patients diagnosed from
2006 to 2013 at the University Hospital Center Osijek,
Osijek, Croatia, were reviewed. We evaluated disease outcome,
overall survival (OS) and event-free survival (EFS),
and demographic, clinical and laboratory factors affecting
outcome. Univariate analysis and Cox regression analysis
were used.
Results Median age of patients was 64 years, 29 were
men (35.8%). Higher RDW levels (%) were found in patients
with advanced Ann Arbor clinical stage (14.94 ± 1.82
vs 13.55 ± 1.54, P = 0.001) and in those with poor response
to therapy (14.94 ± 1.82 vs 13.55 ± 1.54, P = 0.001). Patients
with RDW>15% (cut-off was calculated by receiver operating
characteristics) had significantly worse OS (median
[range], 33 months [20-46] vs 74 months [65-82], P < 0.001)
and EFS (27 months [15-40] vs 68 months [59-77], P < 0.001).
Cox regression analysis showed that RDW>15% was an
independent prognostic factor for OS (HR 3.654, 95% CI
1.128-11.836) and EFS (HR 2.611, 95% CI 1.012-6-739).
Conclusion High baseline RDW is an independent prognostic
marker of poor outcome in patients with DLBCL.
RDW could be an easily available and inexpensive marker
for the risk stratification in patients with DLBCL.
Ključne riječi
Hrčak ID:
151541
URI
Datum izdavanja:
15.8.2015.
Posjeta: 1.563 *