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INCREASED CALCIUM-INDEPENDENT LIPOPROTEIN PHOSPHOLIPASE A2 BUT NOT PROTEIN S100 IN PATIENTS WITH SCHIZOPHRENIA

Maristela Šakić ; Department of Psychiatry, University Hospital Center “Sestre Milosrdnice”, Zagreb, Croatia
Dalibor Karlović orcid.org/0000-0001-6538-7240 ; Department of Psychiatry, University Hospital Center “Sestre Milosrdnice”, Zagreb, Croatia, Croatian Catholic University, Zagreb, Croatia
Branka Vidrih ; Department of Psychiatry, University Hospital Center “Sestre Milosrdnice”, Zagreb, Croatia, Croatian Catholic University, Zagreb, Croatia
Vjekoslav Peitl ; Department of Psychiatry, University Hospital Center “Sestre Milosrdnice”, Zagreb, Croatia
Danijel Crnković ; Department of Psychiatry, University Hospital Center “Sestre Milosrdnice”, Zagreb, Croatia
Nada Vrkić ; Department of Clinical Chemistry, University Hospital Center “Sestre Milosrdnice”, Zagreb, Croatia

Sažetak

Background: The aim of this paper was to investigate serum concentrations of calcium-independent lipoprotein phospholipase
A2 (PLA2) and protein S100 in schizophrenia patients in comparison to healthy controls and correlate them with the clinical
severity, duration, and number of schizophrenia relapses.
Subjects and methods: This study included 65 schizophrenia patients and 70 controls. Schizophrenia was diagnosed according
to DSM-IV-TR criteria. Clinical severity was determined by PANSS. PLA2 and protein S100 concentration were assessed by the
enzyme-linked immunosorbent assay (ELISA).
Results: PLA2 concentrations were higher in patients with schizophrenia, whereas protein S100 concentrations were not. Higher
concentrations of PLA2 were positively correlated with the duration of illness and number of episodes, as determined by multivariate
analysis.
Conclusion: PLA2 might be considered a possible biochemical trait marker for schizophrenia. Further research with larger and
more homogeneous clinical samples is required.

Ključne riječi

schizophrenia - calcium-independent phospholipase A2 - protein S100

Hrčak ID:

154753

URI

https://hrcak.srce.hr/154753

Datum izdavanja:

29.3.2016.

Posjeta: 1.128 *