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Effects of lindane on testosterone metabolism in neuroendocrine organs of male rat

B. Šimić ; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia
J. Kniewald ; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia

Puni tekst: engleski, pdf (5 MB) str. 11-16 preuzimanja: 65* citiraj
APA 6th Edition
Šimić, B. i Kniewald, J. (1985). Effects of lindane on testosterone metabolism in neuroendocrine organs of male rat. Arhiv za higijenu rada i toksikologiju, 36 (1), 11-16. Preuzeto s https://hrcak.srce.hr/156832
MLA 8th Edition
Šimić, B. i J. Kniewald. "Effects of lindane on testosterone metabolism in neuroendocrine organs of male rat." Arhiv za higijenu rada i toksikologiju, vol. 36, br. 1, 1985, str. 11-16. https://hrcak.srce.hr/156832. Citirano 22.07.2019.
Chicago 17th Edition
Šimić, B. i J. Kniewald. "Effects of lindane on testosterone metabolism in neuroendocrine organs of male rat." Arhiv za higijenu rada i toksikologiju 36, br. 1 (1985): 11-16. https://hrcak.srce.hr/156832
Harvard
Šimić, B., i Kniewald, J. (1985). 'Effects of lindane on testosterone metabolism in neuroendocrine organs of male rat', Arhiv za higijenu rada i toksikologiju, 36(1), str. 11-16. Preuzeto s: https://hrcak.srce.hr/156832 (Datum pristupa: 22.07.2019.)
Vancouver
Šimić B, Kniewald J. Effects of lindane on testosterone metabolism in neuroendocrine organs of male rat. Arh Hig Rada Toksikol. [Internet]. 1985 [pristupljeno 22.07.2019.];36(1):11-16. Dostupno na: https://hrcak.srce.hr/156832
IEEE
B. Šimić i J. Kniewald, "Effects of lindane on testosterone metabolism in neuroendocrine organs of male rat", Arhiv za higijenu rada i toksikologiju, vol.36, br. 1, str. 11-16, 1985. [Online]. Dostupno na: https://hrcak.srce.hr/156832. [Citirano: 22.07.2019.]

Sažetak
Experiments were performed in male rats to study the influence of lindane on the activities of hypothalamic and pituitary enzymic systems (5α-R, 3α- and 17β-HSD) involved in testosterone metabolism. Lindane at a concentration of 0.17 .... 0.51 µmoI significantly inhibited the activity of 5α-R (up to 48%), 3α-HSD (up to 41%) and 17β-HSD (up to 29%) in the anterior pituitary. At hypothalamic level the same concentrations of lindane inhibited 5α-R activity (up to 39%), while 3α- and 17β-HSD activities were not affected. The ability of lindane to inhibit the 5α-R, 3α- and 17β-HSD activities at neuroendocrine level suggest that its constant presence at a concentration likely to be found in the organism could have an impact on the reproductive system.

Hrčak ID: 156832

URI
https://hrcak.srce.hr/156832

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Posjeta: 151 *