Izvorni znanstveni članak
Effects of lindane on testosterone metabolism in neuroendocrine organs of male rat
B. Šimić
; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia
J. Kniewald
; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia
Sažetak
Experiments were performed in male rats to study the influence of lindane on the activities of hypothalamic and pituitary enzymic systems (5α-R, 3α- and 17β-HSD) involved in testosterone metabolism. Lindane at a concentration of 0.17 .... 0.51 µmoI significantly inhibited the activity of 5α-R (up to 48%), 3α-HSD (up to 41%) and 17β-HSD (up to 29%) in the anterior pituitary. At hypothalamic level the same concentrations of lindane inhibited 5α-R activity (up to 39%), while 3α- and 17β-HSD activities were not affected. The ability of lindane to inhibit the 5α-R, 3α- and 17β-HSD activities at neuroendocrine level suggest that its constant presence at a concentration likely to be found in the organism could have an impact on the reproductive system.
Ključne riječi
Hrčak ID:
156832
URI
Datum izdavanja:
9.9.1985.
Posjeta: 757 *