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Effects of lindane on testosterone metabolism in neuroendocrine organs of male rat

B. Šimić ; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia
J. Kniewald ; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia


Puni tekst: engleski pdf 5.149 Kb

str. 11-16

preuzimanja: 345

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Sažetak

Experiments were performed in male rats to study the influence of lindane on the activities of hypothalamic and pituitary enzymic systems (5α-R, 3α- and 17β-HSD) involved in testosterone metabolism. Lindane at a concentration of 0.17 .... 0.51 µmoI significantly inhibited the activity of 5α-R (up to 48%), 3α-HSD (up to 41%) and 17β-HSD (up to 29%) in the anterior pituitary. At hypothalamic level the same concentrations of lindane inhibited 5α-R activity (up to 39%), while 3α- and 17β-HSD activities were not affected. The ability of lindane to inhibit the 5α-R, 3α- and 17β-HSD activities at neuroendocrine level suggest that its constant presence at a concentration likely to be found in the organism could have an impact on the reproductive system.

Ključne riječi

Hrčak ID:

156832

URI

https://hrcak.srce.hr/156832

Datum izdavanja:

9.9.1985.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.196 *