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https://doi.org/10.2478/v10007-007-0037-1

Biodegradable inserts for effective management of periodontitis: Preparation and in vitro evaluation

ROMI BARAT
ANEGUNDHA SRINATHA
JAYANTA K. PANDIT
SHEMPA ANUPURBA
NEELAM MITTAL


Puni tekst: engleski pdf 106 Kb

str. 469-477

preuzimanja: 1.007

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Sažetak

Chitosan based metronidazole (MZ) inserts were fabricated by the casting method and characterized with respect to mass and thickness uniformity, metronidazole loading and in vitro metronidazole release kinetics. The fabricated inserts exhibited satisfactory physical characteristics. The mass of inserts was in the range of 5.63 ± 0.42 to 6.04 ± 0.89 mg. The thickness ranged from 0.46 ± 0.06 to 0.49 ± 0.08 mm. Metronidazole loading was in the range of 0.98 ± 0.09 to 1.07 ± 0.07 mg except for batch CM3 with MZ loading of 2.01 ± 0.08 mg. The inserts exhibited an initial burst release at the end of 24 h, irrespective of the drug to polymer ratio, plasticizer content or cross-linking. However, further drug release was sustained over the next 6 days. Cross-linking with 10% (m/m) of glutaraldehyde inhibited the burst release by ~30% and increased the mean dissolution time (MDT) from 0.67 to 8.59 days. The decrease in drug release was a result of reduced permeability of chitosan due to cross-linking.

Ključne riječi

chitosan inserts; cross-linking; metronidazole; periodontitis; sustained release

Hrčak ID:

15953

URI

https://hrcak.srce.hr/15953

Datum izdavanja:

1.12.2007.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.282 *