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»Antabus test« and absenteeism in workers exposed to carbon disulfide

M. Besarabić ; »Incel« Health Unit, Medical Centre Banja Luka, Banja Luka

Puni tekst: engleski pdf 3.011 Kb

str. 323-326

preuzimanja: 200



This study represents our attempt to find a method for the pre-employment selection of workers in a viscose fibre plant. »Antabus test« was applied to 61 workers in a viscose factory exposed to carbon disulfide up to 4.5 years. After oral administration of 0.5 g Antabus (TETD, Disulfiram) the excretion of diethyldithiocarbamate (DDC) was determined in a four-hour urine sample. The workers were divided into four groups according to the quantitiy of the excreted DDC. Data on absenteeism and specific morbidity were correlated between the groups. It was evident that with an increase in DDC excretion the specific morbidity and absenteeism decreased. In workers excreting more than 150 µg of DDC/mg creatinine no absenteeism or specific morbidity were recorded. It seems that this group was naturally resistant to CS2. The test has been applied in the selection of new workers. Only persons with a DDC excretion over 150 µg/mg creatinine were accepted for the job with CS2 hazard. However, further investigations are necessary to establish if »Antabus test« represents a reliable test for the assessment of individual sensitivity to CS2.

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