Kratko priopćenje

WHEN DO PSYCHIATRIC SIDE EFFECTS EMERGE DURING ANTIVIRAL TREATMENT OF HEPATITIS C?

Gábor Gazdag orcid.org/0000-0002-6914-8041 ; Center for Psychiatry and Addiction Medicine, Szent István and Szent László Hospital, Budapest, Hungary; Department of Psychiatry and Psychotherapy, Semmelweis University, Faculty of Medicine, Budapest, Hungary
Gergely Horváth ; Hungarian Drug Focal Point, National Center for Epidemiology, Budapest, Hungary
Olga Szabó ; Hepatology Outpatient Clinic, Szent István and Szent László Hospitals, Budapest, Hungary
Rozália Takács ; 1st Department of Psychiatry, Nyirö Gyula Hospital, Budapest, Hungary
Gabor S. Ungvari ; University of Notre Dame Australia/Marian Centre, Perth, Australia; School of Psychiatry & Clinical Neurosciences, University of Western Australia, Perth, Australia

Sažetak

Background: This retrospective study aimed to determine the time-frame regarding the first appearance of psychiatric side
effects in the course of antiviral treatment and the subsequent referral to consultation-liaison psychiatric services.
Subjects and methods: Medical records of patients receiving combined antiviral treatment with alpha interferon and ribavirin
for hepatitis C at a hepatology outpatient clinic and referred to psychiatric consultation between April 2000 and July 2011 were
scrutinized.
Results: Time between the initiation of antiviral treatment and the first appearance of psychiatric symptoms was 10.64±10.68
weeks. Patients were referred to psychiatric examination 16.1±12.7 weeks after antiviral treatment had been commenced. The time
frame of the emergence of psychiatric symptoms and the referral for psychiatric consultation did not correlate with the patients’ age
or sex. No relationship between substance/alcohol abuse and psychiatric history and the timing of psychiatric side effects and their
assessment were found.
Conclusions: This study confirmed that psychiatric side effects appear late in the course of combined antiviral treatment arising
after 10.64±10.68 weeks the treatment started. The results also showed that some patients’ psychiatric symptoms appeared
immediately after the beginning of the antiviral therapy. This finding underlines the importance of monitoring patients’ psychiatric
condition as soon as antiviral treatment commences.

Ključne riječi

hepatitis C - antiviral treatment - psychiatric side effects - substance/alcohol abuse - depression

Hrčak ID:

162116

URI

https://hrcak.srce.hr/162116

Datum izdavanja:

16.12.2013.

Posjeta: 513 *