Izvorni znanstveni članak
The effect of nitrogen oxides and products of their neutralization by ammonia on the hematopoietic system in guinea pigs
S. Košmider
; II Clinic of Internal Diseases, Clinic of Occupational Diseases and Clinical Toxicology, and Institute of Internal Diseases, Silesian School of Medicine, Katowice, Poland
A. Misiewicz
; II Clinic of Internal Diseases, Clinic of Occupational Diseases and Clinical Toxicology, and Institute of Internal Diseases, Silesian School of Medicine, Katowice, Poland
A. Wegiel
; II Clinic of Internal Diseases, Clinic of Occupational Diseases and Clinical Toxicology, and Institute of Internal Diseases, Silesian School of Medicine, Katowice, Poland
Sažetak
The effect of nitrogen oxides on the hematopoietic system was studied. The experiments were carried out on 90 guinea pigs. The animals were divided into three equal groups: a control group (A), a group (B) exposed to nitrogen oxides at a concentration of 1 mg/m3, eight hours a day for a period of 120 days and a third group (C), which was exposed to the reaction products of nitrogen oxides and ammonia for 120 days. It was shown that nitrogen oxides stimulate erythropoiesis which resulted in a marked accumulation of erythrocytic cells in the bone marrow. The proportion of the erythropoietic to the leukocytic system was 1 : 1, while in the control group it was 1 : 2. At the same time an increased number of red cell reticulocytes and an elevated hemoglobin level were observed. The observed increase of ALA-D activity in erythrocytes with a simultaneous decrease in the urinary elimination of ALA and an increased elimination of coproporphyrins was quite an interesting phenomen. These data might be indicative of an intensified hem synthesis. The neutralization of nitrogen oxides by gaseous ammonia led to the formation of reaction products and under their influence the picture of the peripheral blood and bone marrow became similar to that observed in the control group.
Ključne riječi
Hrčak ID:
165212
URI
Datum izdavanja:
29.6.1977.
Posjeta: 1.173 *