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Cyclodextrins: Application in different routes of drug administration

SHYAM SHIMPI
BHASKAR CHAUHAN
PRAJAKTA SHIMPI

Puni tekst: engleski, pdf (107 KB) str. 139-156 preuzimanja: 5.036* citiraj
APA 6th Edition
SHIMPI, S., CHAUHAN, B. i SHIMPI, P. (2005). Cyclodextrins: Application in different routes of drug administration. Acta Pharmaceutica, 55 (2), 139-156. Preuzeto s https://hrcak.srce.hr/16752
MLA 8th Edition
SHIMPI, SHYAM, et al. "Cyclodextrins: Application in different routes of drug administration." Acta Pharmaceutica, vol. 55, br. 2, 2005, str. 139-156. https://hrcak.srce.hr/16752. Citirano 25.06.2019.
Chicago 17th Edition
SHIMPI, SHYAM, BHASKAR CHAUHAN i PRAJAKTA SHIMPI. "Cyclodextrins: Application in different routes of drug administration." Acta Pharmaceutica 55, br. 2 (2005): 139-156. https://hrcak.srce.hr/16752
Harvard
SHIMPI, S., CHAUHAN, B., i SHIMPI, P. (2005). 'Cyclodextrins: Application in different routes of drug administration', Acta Pharmaceutica, 55(2), str. 139-156. Preuzeto s: https://hrcak.srce.hr/16752 (Datum pristupa: 25.06.2019.)
Vancouver
SHIMPI S, CHAUHAN B, SHIMPI P. Cyclodextrins: Application in different routes of drug administration. Acta Pharm. [Internet]. 2005 [pristupljeno 25.06.2019.];55(2):139-156. Dostupno na: https://hrcak.srce.hr/16752
IEEE
S. SHIMPI, B. CHAUHAN i P. SHIMPI, "Cyclodextrins: Application in different routes of drug administration", Acta Pharmaceutica, vol.55, br. 2, str. 139-156, 2005. [Online]. Dostupno na: https://hrcak.srce.hr/16752. [Citirano: 25.06.2019.]

Sažetak
The objective of this review article is to explain the use of cyclodextrin in the different routes of drug administration. The article gives the chemistry of cyclodextrins and addresses the issue of the mechanism of drug release from cyclodextrin complexes. Dilution, competitive displacement, protein binding, change in ionic strength and temperature and drug uptake by tissues are the different release mechanisms of the drug from the drug-cyclodextrin complex discussed here. Use and its limitations in the different drug delivery systems like nasal, ophthalmic, transdermal and rectal drug delivery are explained. The application of the cyclodextrins in the oral drug delivery is detailed in this review. Many studies have shown that cyclodextrins are used as useful additives in the routes of drug administration because of increased aqueous solubility, stability, bioavailability and reduced drug irritation.

Ključne riječi
cyclodextrins; release mechanism; nasal drug delivery; ophthalmic drug delivery; transdermal drug delivery; rectal drug delivery; oral drug delivery

Hrčak ID: 16752

URI
https://hrcak.srce.hr/16752

[hrvatski]

Posjeta: 6.162 *