Acta Pharmaceutica, Vol. 55 No. 2, 2005.
Izvorni znanstveni članak
Thermodynamic study of the transfer of acetanilide and phenacetin from water to different organic solvents
YOLIMA BAENA
JORGE A. PINZÓN
HELBER J. BARBOSA
FLMING MARTÍNEZ
Sažetak
The molar (KCo/w) and rational (KXo/w) partition coefficients in the octanol/buffer, i-propyl myristate/buffer, chloroform/buffer, and cyclohexane/buffer systems were determined for acetanilide and phenacetin at 25.0, 30.0, 35.0, and 40.0 °C. In all cases except for cyclohexane, the KCo/w and KXo/w values were greater than unity. This demonstrates that these two drugs have predominantly lipophilic behavior. Gibbs and van't Hoff thermodynamic analyses have revealed that the transfer of these drugs from water to organic solvents is spontaneous and that it is mainly driven enthalpically for i-propyl myristate and chloroform, and entropy-driven for octanol and cyclohexane.
Ključne riječi
acetanilide; phenacetin; partition coefficient; thermodynamics
Hrčak ID:
16757
URI
Datum izdavanja:
1.6.2005.
Posjeta: 1.906 *