Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2016.57.119
The effects of anthocyaninrich wheat diet on the oxidative status and behavior of rats
Katarína Janšáková
; Institute of Molecular Biomedicine Faculty of Medicine, Comenius University, Bratislava, Slovakia
Janka Bábíčková
; Institute of Molecular Biomedicine Faculty of Medicine, Comenius University, Bratislava, Slovakia
Michaela Havrlentová
; Research Institute of Plant Production, Piešťany, Slovakia
Július Hodosy
; Institute of Physiology, Faculty of Medicine, Comenius University,
Ján Kraic
; Research Institute of Plant Production, Piešťany, Slovakia
Sažetak
Aim To evaluate the effect of food containing anthocyanin-
rich wheat on oxidative status and behavior of healthy
rats.
Methods Twenty male rats were divided into the control
and anthocyanin group. Oral glucose tolerance test was
performed, and proteinuria and creatinine clearance were
measured. Behavioral analysis was performed in Phenotyper
cages. Serum and tissues were collected to measure
the markers of oxidative stress and antioxidant status.
Results Anthocyanins significantly increased total antioxidant
capacity in serum (P = 0.039), decreased advanced
oxidation protein products in the kidney (P = 0.002), but
increased thiobarbituric acid reactive substances in the
kidney compared to the control group. No significant difference
between the groups was found in the markers
of oxidative stress in the liver and colon, as well as in renal
functions and glucose metabolism. The anthocyanin
group spent significantly less time in the spotlight zone of
the Phenotyper cages (P = 0.040), indicating higher anxiety-
like behavior.
Conclusion Food containing anthocyanin-rich wheat had
positive effects on serum antioxidant status and kidney
protein oxidation, but increased lipid peroxidation in the
kidney and modified animal behavior related to anxiety.
The molecular mechanisms leading to observed effects
should be further elucidated.
Ključne riječi
Hrčak ID:
169472
URI
Datum izdavanja:
15.4.2016.
Posjeta: 875 *