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https://doi.org/10.3325/cmj.2016.57.276

Vitamin D levels and their associations with survival and major disease outcomes in a large cohort of patients with chronic graft-vs-host disease

Mašenjka Katić   ORCID icon orcid.org/0000-0001-7237-697X ; Experimental Transplantation and Immunology Branch, NCI, NIH,Bethesda, MD, USA
Filip Pirsl ; Experimental Transplantation and Immunology Branch, NCI, NIH,Bethesda, MD, USA
Seth M. Steinberg ; Biostatistics and Data Management Section, NCI, NIHRockville, MD, USA
Marnie Dobbin ; Clinical Nutrition Department Clinical Center, NIH, Bethesda, MD,USA
Lauren M. Curtis ; Experimental Transplantation and Immunology Branch, NCI, NIH,Bethesda, MD, USA
Dražen Pulanić ; Division of Hematology Department of Internal Medicine,University Hospital Center Zagreb,Zagreb, Croatia
Lana Desnica ; Division of Hematology Department of Internal Medicine,University Hospital Center Zagreb,Zagreb, Croatia
Irina Titarenko ; Center for Cancer Research, NIH, Bethesda, MD, USA

Puni tekst: engleski, pdf (630 KB) str. 276-286 preuzimanja: 266* citiraj
APA 6th Edition
Katić, M., Pirsl, F., Steinberg, S.M., Dobbin, M., Curtis, L.M., Pulanić, D., ... Titarenko, I. (2016). Vitamin D levels and their associations with survival and major disease outcomes in a large cohort of patients with chronic graft-vs-host disease. Croatian Medical Journal, 57 (3), 276-286. https://doi.org/10.3325/cmj.2016.57.276
MLA 8th Edition
Katić, Mašenjka, et al. "Vitamin D levels and their associations with survival and major disease outcomes in a large cohort of patients with chronic graft-vs-host disease." Croatian Medical Journal, vol. 57, br. 3, 2016, str. 276-286. https://doi.org/10.3325/cmj.2016.57.276. Citirano 27.07.2021.
Chicago 17th Edition
Katić, Mašenjka, Filip Pirsl, Seth M. Steinberg, Marnie Dobbin, Lauren M. Curtis, Dražen Pulanić, Lana Desnica i Irina Titarenko. "Vitamin D levels and their associations with survival and major disease outcomes in a large cohort of patients with chronic graft-vs-host disease." Croatian Medical Journal 57, br. 3 (2016): 276-286. https://doi.org/10.3325/cmj.2016.57.276
Harvard
Katić, M., et al. (2016). 'Vitamin D levels and their associations with survival and major disease outcomes in a large cohort of patients with chronic graft-vs-host disease', Croatian Medical Journal, 57(3), str. 276-286. https://doi.org/10.3325/cmj.2016.57.276
Vancouver
Katić M, Pirsl F, Steinberg SM, Dobbin M, Curtis LM, Pulanić D i sur. Vitamin D levels and their associations with survival and major disease outcomes in a large cohort of patients with chronic graft-vs-host disease. Croat Med J. [Internet]. 2016 [pristupljeno 27.07.2021.];57(3):276-286. https://doi.org/10.3325/cmj.2016.57.276
IEEE
M. Katić, et al., "Vitamin D levels and their associations with survival and major disease outcomes in a large cohort of patients with chronic graft-vs-host disease", Croatian Medical Journal, vol.57, br. 3, str. 276-286, 2016. [Online]. https://doi.org/10.3325/cmj.2016.57.276

Sažetak
Aim To identify the factors associated with vitamin D status
in patients with chronic graft-vs-host disease (cGVHD) and
evaluate the association between serum vitamin D (25(OH)
D) levels and cGVHD characteristics and clinical outcomes
defined by the National Institutes of Health (NIH) criteria.
Methods 310 cGVHD patients enrolled in the NIH cGVHD
natural history study (clinicaltrials.gov: NCT00092235)
were analyzed. Univariate analysis and multiple logistic
regression were used to determine the associations between
various parameters and 25(OH)D levels, dichotomized
into categorical variables: ≤20 and >20 ng/mL, and
as a continuous parameter. Multiple logistic regression was
used to develop a predictive model for low vitamin D. Survival
analysis and association between cGVHD outcomes
and 25(OH)D as a continuous as well as categorical variable:
≤20 and >20 ng/mL; <50 and ≥50 ng/mL, and among
three ordered categories: ≤20, 20-50, and ≥50 ng/mL, was
performed.
Results 69 patients (22.3%) had serum 25(OH)D ≤20 ng/
mL. Univariate analysis showed that supplement intake,
nutritional status (severely malnourished, moderately malnourished,
well-nourished), race (African-American, other),
and estimated creatinine clearance (eCCr) were associated
with 25(OH)D levels. A predictive model was developed
based on supplement intake, nutritional status, race, and
eCCr, accurately predicting 77.9% of patients with 25(OH)
D ≤20 and 65.2% of those with 25(OH)D >20 ng/mL. No association
was found between vitamin D and major cGVHD
characteristics, but patients with 25(OH)D ≤20 ng/mL had
somewhat decreased survival.
Conclusion Nutritional status and adequate supplementation
are important to maintain 25(OH)D >20 ng/mL in
cGVHD patients. Intervention studies and more research is
needed to reveal the underlying mechanism of vitamin D
metabolism in cGVHD setting.

Hrčak ID: 170168

URI
https://hrcak.srce.hr/170168

Posjeta: 422 *