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Influence of the route of exposure on the acute toxicity of cholinesterase inhibitors

I.L. Natoff ; Shell Research Limited, Tunstall Laboratory, Sittingbourne, Kent, England

Puni tekst: engleski, pdf (4 MB) str. 347-352 preuzimanja: 74* citiraj
APA 6th Edition
Natoff, I.L. (1970). Influence of the route of exposure on the acute toxicity of cholinesterase inhibitors. Arhiv za higijenu rada i toksikologiju, 21 (4), 347-352. Preuzeto s https://hrcak.srce.hr/172840
MLA 8th Edition
Natoff, I.L.. "Influence of the route of exposure on the acute toxicity of cholinesterase inhibitors." Arhiv za higijenu rada i toksikologiju, vol. 21, br. 4, 1970, str. 347-352. https://hrcak.srce.hr/172840. Citirano 19.04.2021.
Chicago 17th Edition
Natoff, I.L.. "Influence of the route of exposure on the acute toxicity of cholinesterase inhibitors." Arhiv za higijenu rada i toksikologiju 21, br. 4 (1970): 347-352. https://hrcak.srce.hr/172840
Harvard
Natoff, I.L. (1970). 'Influence of the route of exposure on the acute toxicity of cholinesterase inhibitors', Arhiv za higijenu rada i toksikologiju, 21(4), str. 347-352. Preuzeto s: https://hrcak.srce.hr/172840 (Datum pristupa: 19.04.2021.)
Vancouver
Natoff IL. Influence of the route of exposure on the acute toxicity of cholinesterase inhibitors. Arh Hig Rada Toksikol. [Internet]. 1970 [pristupljeno 19.04.2021.];21(4):347-352. Dostupno na: https://hrcak.srce.hr/172840
IEEE
I.L. Natoff, "Influence of the route of exposure on the acute toxicity of cholinesterase inhibitors", Arhiv za higijenu rada i toksikologiju, vol.21, br. 4, str. 347-352, 1970. [Online]. Dostupno na: https://hrcak.srce.hr/172840. [Citirano: 19.04.2021.]

Sažetak
The acute toxicities of some cholinesterase inhibitor compounds have been determined by the oral, intraperitoneal, subcutaneous, intravenous and intracerebral routes of injection in female mice. The coupounds studied were monocrotophos, dicrotophos, mevinphos, crotoxyphos, dichlorvos, chlorfenvinphos, paraoxon, parathion, neostigmine and eserine. Compounds which are rapidly degraded by the liver are less toxic following oral and intraperitoneal (hepatic routes) injection than they are by subcutaneous and intravenous (peripheral routes) injection. Parathion, which is activated by the liver, tends to be more toxic following administration by the intraperitoneal (hepatic) route. Intracerebral injection by-passes the blood-brain barrier, and the compounds show, with one or two exceptions, a similar order of toxicity by this route of administration compared with the other routes of injection.

Hrčak ID: 172840

URI
https://hrcak.srce.hr/172840

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