Croatica Chemica Acta, Vol. 58 No. 4, 1985.
Izvorni znanstveni članak
Synthesis of (+)-Officinalic Acid
Bernhard Erb
; Laboratorium fur Organische Chemie der ETH Zurich, Universitatstrasse 16, CH-8092 Zurich, Switzerland
Hans-Jurg Borschberg
; Laboratorium fur Organische Chemie der ETH Zurich, Universitatstrasse 16, CH-8092 Zurich, Switzerland
Duilio Arigoni
; Laboratorium fur Organische Chemie der ETH Zurich, Universitatstrasse 16, CH-8092 Zurich, Switzerland
Sažetak
A new concept for the biosynthesis of officinalic acid (1), a C30-metabolitefrom the fungus Laricifomes officinalis, had led to an efficient synthesis of the racemic form of this compound. The key step involves a Diels-Alder dimerization of the readily available enone acid (±)-3, which furnishes (±)-officinalic acid in 420/0 yield. A byproduct formed in the same reaction in 10% yield has been named isoofficinalic acid and shown by spectroscopic techniques to possess structure 11.
Ključne riječi
Hrčak ID:
178052
URI
Datum izdavanja:
6.3.1986.
Posjeta: 794 *