Izvorni znanstveni članak

The pharmacokinetics of enrofloxacin in ducks with steatosis after force-feeding

Neno Bratoev ; Department of Pharmacology, Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria
Aneliya Milanova ; Department of Pharmacology, Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria
Dimitrichka Dimitrova ; Department of Pharmacology, Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria
Rumyana Moutafchieva ; Department of Pharmacology, Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria
Ivelina Pavlova ; Department of Pharmacology, Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria
Lubomir Lashev ; Department of Pharmacology, Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria

Sažetak

The pharmacokinetics of enrofloxacin (EFC) was investigated in ducks fed with a normal diet, and in force-fed ducks, after a single intravenous (i.v.) and oral (p.o.) administration at doses of 10 mg/kg. Serum concentrations of EFC and ciprofloxacin (as metabolite of EFC) were determined by the HPLC method. The elimination half-lives of EFC after i.v. administration and compartmental pharmacokinetic analysis were 4.62 ± 0.62h and 6.39 ± 2.78 h in healthy and force-fed ducks, respectively. The values of total body clearance were 0.24 ± 0.03 L/h/kg in healthy and 0.18 ± 0.02 L/h/kg in force-fed ducks. The values of the volume of distribution (Vss) were 1.32 ± 0.18 L/kg and 1.31 ± 0.21 L/kg, respectively. After oral administration, maximum serum concentrations were 1.95 ± 0.36 µg/mL reached at 3.67 ± 4.26 h, and 4.25 ± 1.21 µg/mL at 1.25 ± 0.88 h, respectively. The serum concentrations of ciprofloxacin were significantly lower in the force-fed ducks. Longer enrofloxacin residence in force-fed ducks can be expected if compared to normally fed animals.

Ključne riječi

pharmacokinetics; enrofloxacin; ducks; force-feeding steatosis

Hrčak ID:

178603

URI

https://hrcak.srce.hr/178603

Datum izdavanja:

15.3.2017.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.026 *