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https://doi.org/10.5562/cca3016

HPLC Monitoring of Acid Catalyzed Conversion of 7-Ethyltryptophol to Methyl Ester of Etodolac

Iva Habinovec ; Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, HR-10000 Zagreb, Croatia
Željka Car ; Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, HR-10000 Zagreb, Croatia
Rosana Ribić ; Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, HR-10000 Zagreb, Croatia
Nives Galić   ORCID icon orcid.org/0000-0002-0958-1791 ; Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, HR-10000 Zagreb, Croatia
Predrag Novak ; Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, HR-10000 Zagreb, Croatia
Ernest Meštrović ; PLIVA TEVA Croatia, Prilaz Baruna Filipovića 29, HR-10000 Zagreb, Croatia
Srđanka Tomić ; Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, HR-10000 Zagreb, Croatia

Puni tekst: engleski, pdf (672 KB) str. 549-553 preuzimanja: 441* citiraj
APA 6th Edition
Habinovec, I., Car, Ž., Ribić, R., Galić, N., Novak, P., Meštrović, E. i Tomić, S. (2016). HPLC Monitoring of Acid Catalyzed Conversion of 7-Ethyltryptophol to Methyl Ester of Etodolac. Croatica Chemica Acta, 89 (4), 549-553. https://doi.org/10.5562/cca3016
MLA 8th Edition
Habinovec, Iva, et al. "HPLC Monitoring of Acid Catalyzed Conversion of 7-Ethyltryptophol to Methyl Ester of Etodolac." Croatica Chemica Acta, vol. 89, br. 4, 2016, str. 549-553. https://doi.org/10.5562/cca3016. Citirano 22.11.2019.
Chicago 17th Edition
Habinovec, Iva, Željka Car, Rosana Ribić, Nives Galić, Predrag Novak, Ernest Meštrović i Srđanka Tomić. "HPLC Monitoring of Acid Catalyzed Conversion of 7-Ethyltryptophol to Methyl Ester of Etodolac." Croatica Chemica Acta 89, br. 4 (2016): 549-553. https://doi.org/10.5562/cca3016
Harvard
Habinovec, I., et al. (2016). 'HPLC Monitoring of Acid Catalyzed Conversion of 7-Ethyltryptophol to Methyl Ester of Etodolac', Croatica Chemica Acta, 89(4), str. 549-553. https://doi.org/10.5562/cca3016
Vancouver
Habinovec I, Car Ž, Ribić R, Galić N, Novak P, Meštrović E i sur. HPLC Monitoring of Acid Catalyzed Conversion of 7-Ethyltryptophol to Methyl Ester of Etodolac. Croatica Chemica Acta [Internet]. 2016 [pristupljeno 22.11.2019.];89(4):549-553. https://doi.org/10.5562/cca3016
IEEE
I. Habinovec, et al., "HPLC Monitoring of Acid Catalyzed Conversion of 7-Ethyltryptophol to Methyl Ester of Etodolac", Croatica Chemica Acta, vol.89, br. 4, str. 549-553, 2016. [Online]. https://doi.org/10.5562/cca3016

Sažetak
Small scale experimental model for the preparation of methyl ester of etodolac, the key intermediate in the synthesis of nonsteroidal drug etodolac, is thoroughly investigated in order to define the key parameters needed for its large scale production. Oxa-Pictet-Spengler reaction of 7-ethyltryptophol and methyl 3-oxopentanoate with inorganic acids as catalysts was monitored over time using HPLC method with UV detection. HPLC method for the simultaneous determination of 7-ethyltryptophol and the product was developed first. The conversion of 7-ethyltryptophol to etodolac precursor was performed using different molar equivalents of acid (1-5 with respect to the β-ketoester) and starting 7-ethyltryptophol of different degrees of purity. Kinetic profiles and optimal reaction times were in each case defined and key parameters selected.

Ključne riječi
HPLC method; kinetic profile; Oxa-Pictet-Spengler reaction; etodolac methyl ester

Hrčak ID: 180780

URI
https://hrcak.srce.hr/180780

Posjeta: 570 *